Balakhadze Mariam, Giorgadze Elene, Lomidze Marina
Ivane Javakhishvili Tbilisi State University, 0179 Tbilisi, Georgia; V. Iverieli Endocrinology Metabology Dietology Center "ENMEDIC", 9 Tsinandali Street, 0144 Tbilisi, Georgia.
Ivane Javakhishvili Tbilisi State University, 0179 Tbilisi, Georgia; National Institute of Endocrinology, 2/6 Lubliana Street, 0159 Tbilisi, Georgia.
Int J Endocrinol. 2016;2016:6597091. doi: 10.1155/2016/6597091. Epub 2016 Jun 27.
Aim. Chronic autoimmune thyroiditis and type 1 diabetes mellitus are organ-specific autoimmune diseases. There is large evidence that autoimmunity against the thyroid gland in patients with type 1 diabetes mellitus is increased, but little is known about anti-islet cell autoimmune status in patients with chronic autoimmune thyroiditis. We evaluated the concentration of antibodies against glutamic acid decarboxylase (GAD) which are widely used as a diagnostic and predictive tool for type 1 diabetes mellitus, in school-aged Georgian children with chronic autoimmune thyroiditis. Methods. The frequency of anti-GAD antibodies was measured in Georgian school-aged children with chronic autoimmune thyroiditis and compared to healthy age and sex matched controls. Results. Of the 41 patients with chronic autoimmune thyroiditis 4 (9.8%) were positive for GAD antibodies. The frequency of GAD positivity in the chronic autoimmune thyroiditis group was significantly higher than in the control subjects (P = 0.036). Conclusion. In the study we found that the frequency of GAD antibody positivity in autoimmune thyroiditis patients was significantly higher (9.8%, P = 0.036) than in the control group. Our findings support the concept that patients with autoimmune thyroid disease may develop type 1 diabetes mellitus in future life.
目的。慢性自身免疫性甲状腺炎和1型糖尿病是器官特异性自身免疫性疾病。有大量证据表明，1型糖尿病患者针对甲状腺的自身免疫性增强，但对于慢性自身免疫性甲状腺炎患者的抗胰岛细胞自身免疫状态了解甚少。我们评估了格鲁吉亚学龄儿童慢性自身免疫性甲状腺炎患者中谷氨酸脱羧酶（GAD）抗体的浓度，该抗体广泛用作1型糖尿病的诊断和预测工具。方法。测量格鲁吉亚学龄慢性自身免疫性甲状腺炎儿童中抗GAD抗体的频率，并与年龄和性别匹配的健康对照进行比较。结果。41例慢性自身免疫性甲状腺炎患者中，4例（9.8%）GAD抗体呈阳性。慢性自身免疫性甲状腺炎组中GAD阳性频率显著高于对照组（P = 0.036）。结论。在该研究中，我们发现自身免疫性甲状腺炎患者中GAD抗体阳性频率（9.8%，P = 0.036）显著高于对照组。我们的研究结果支持自身免疫性甲状腺疾病患者未来可能发展为1型糖尿病这一观点。
