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De-escalation of pivotal beta-lactam in ventilator-associated pneumonia does not impact outcome and marginally affects MDR acquisition.

作者信息

Weiss E, Zahar J R, Garrouste-Orgeas M, Ruckly S, Essaied W, Schwebel C, Timsit J F

机构信息

Department of Anesthesiology and Critical Care, AP-HP, Hôpital Beaujon, Paris Diderot University, 92110, Clichy, France.

Infection Control Unit, Hôpital d'Angers, Angers University, 49000, Angers, France.

出版信息

Intensive Care Med. 2016 Dec;42(12):2098-2100. doi: 10.1007/s00134-016-4448-7. Epub 2016 Jul 18.

DOI:10.1007/s00134-016-4448-7
PMID:27430221
Abstract
摘要

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Clin Infect Dis. 2016 Apr 15;62(8):1009-1017. doi: 10.1093/cid/civ1199. Epub 2015 Dec 23.
2
Elaboration of a consensual definition of de-escalation allowing a ranking of β-lactams.制定一项共识定义的降级治疗方案，允许对β-内酰胺类药物进行分级。
Clin Microbiol Infect. 2015 Jul;21(7):649.e1-10. doi: 10.1016/j.cmi.2015.03.013. Epub 2015 Apr 13.
3
Emergence of imipenem-resistant gram-negative bacilli in intestinal flora of intensive care patients.
Antimicrobial De-Escalation in Critically Ill Patients.危重症患者的抗菌药物降阶梯治疗
Antibiotics (Basel). 2024 Apr 19;13(4):375. doi: 10.3390/antibiotics13040375.
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Effect of antimicrobial de-escalation strategy on 14-day mortality among intensive care unit patients: a retrospective propensity score-matched cohort study with inverse probability-of-treatment weighting.抗菌药物降阶梯策略对重症监护病房患者 14 天死亡率的影响：一项采用逆概率治疗加权的回顾性倾向评分匹配队列研究。
BMC Infect Dis. 2023 Aug 4;23(1):508. doi: 10.1186/s12879-023-08491-7.
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Antibiotic De-Escalation in Critically Ill Patients with Negative Clinical Cultures.临床培养结果为阴性的重症患者的抗生素降阶梯治疗
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