Fidan Kibriya, Isik Gonul Ipek, Büyükkaragöz Bahar, Isiyel Emel, Arinsoy Turgay, Soylemezoglu Oguz
a Division of Pediatric Nephrology , Gazi University , Ankara , Turkey ;
b Division of Nephropathology , Gazi University , Ankara , Turkey ;
Ren Fail. 2016 Sep;38(8):1228-33. doi: 10.1080/0886022X.2016.1209070. Epub 2016 Jul 18.
Renal biopsy is the gold standard method for determining the diagnosis, treatment, and prognosis in children with renal disease. This study aims to evaluate the histopathological features of pediatric renal biopsies obtained from the national nephrology registry in the last two decades. Data recorded in the Turkish Society of Nephrology Registry System (TSNRS) in 1991 as well as in between 2001 and 2010 were analyzed. A total of 3892 biopsies were recorded; with the least number in 1991 (total 103 biopsies from 17 centers) and the highest number in 2008 (total 654 biopsies from 23 centers). Glomerular diseases constituted the main group in the registry (62.64%), followed by systemic diseases (20.06%). Focal and segmental glomerulosclerosis (FSGS) and Henoch-Schönlein purpura (HSP) nephritis (IgA vasculitis) were the most common glomerular and systemic diseases, respectively. Overall prevalence of renal amyloidosis and membranous nephropathy (MN) was quite low (1.87% and 1.56%, respectively) in all periods. Compared to 1991, there was an increasing trend in the frequencies of certain disorders including hemolytic uremic syndrome (HUS), IgA nephropathy, and HSP nephritis; and there was a decrease in acute proliferative glomerulonephritis (GN) in 2008. As well as demonstrating the etiologies of renal diseases which can only be identified by renal biopsies, this study provides important information regarding the changing patterns of histopathological findings due to better management of pediatric renal diseases over the years in Turkey.
肾活检是确定儿童肾病诊断、治疗和预后的金标准方法。本研究旨在评估过去二十年从国家肾脏病登记处获得的儿科肾活检的组织病理学特征。对1991年以及2001年至2010年间土耳其肾脏病学会登记系统（TSNRS）记录的数据进行了分析。共记录了3892例活检病例；1991年数量最少（来自17个中心的共103例活检），2008年数量最多（来自23个中心的共654例活检）。肾小球疾病是登记中的主要组（62.64%），其次是全身性疾病（20.06%）。局灶节段性肾小球硬化（FSGS）和过敏性紫癜（HSP）肾炎（IgA血管炎）分别是最常见的肾小球疾病和全身性疾病。在所有时期，肾淀粉样变性和膜性肾病（MN）的总体患病率相当低（分别为1.87%和1.56%）。与1991年相比，包括溶血尿毒综合征（HUS）、IgA肾病和HSP肾炎在内的某些疾病的发生率呈上升趋势；2008年急性增生性肾小球肾炎（GN）有所下降。本研究不仅展示了只能通过肾活检确定的肾病病因，还提供了有关土耳其多年来儿科肾病管理改善导致的组织病理学发现变化模式的重要信息。
