Fujiwara Atsushi, Morizane Yuki, Hosokawa Mio, Kimura Shuhei, Kumase Fumiaki, Shiode Yusuke, Doi Shinichiro, Hirano Masayuki, Toshima Shinji, Hosogi Mika, Shiraga Fumio
Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
Am J Ophthalmol. 2016 Oct;170:1-9. doi: 10.1016/j.ajo.2016.07.006. Epub 2016 Jul 16.
To quantify the vascular density of the choroid of normal eyes and to identify the influencing factors using en face images obtained with swept-source optical coherence tomography (SS OCT).
Prospective cross-sectional study.
One hundred and sixty-three eyes of 163 healthy volunteers (83 female; mean age 42.2 ± 22.6 years) with a corrected visual acuity of ≥1.0 were investigated. En face SS OCT images of the choroid were used for quantitative assessment of the vascular density in the large choroid vessel layer. Relationships between vascular density of the choroid and age, sex, refractive error (RE), axial length (AL), and subfoveal choroidal thickness (SCT) were also investigated.
There was a significant negative relationship between vascular density of the choroid and subject age (P < .001). Analysis according to age showed a significant correlation in the group aged >30 years (P < .001), but not in the group aged ≤30 years (P = .225). SCT had a significant positive relationship with vascular density of the choroid (P < .001). However, a significant correlation was not observed between sex, RE, or AL and vascular density of the choroid (P = .981, P = .292, and P = .216, respectively). Multivariable regression analysis with vascular density of the choroid as the dependent variable and age, sex, RE, AL, and SCT as independent variables showed that age and SCT are important determinants of vascular density of the choroid (P < .001).
Age and SCT affect vascular density of the choroid.
使用扫频光学相干断层扫描（SS OCT）获得的眼底图像，量化正常眼睛脉络膜的血管密度，并确定影响因素。
前瞻性横断面研究。
对163名健康志愿者（83名女性；平均年龄42.2±22.6岁）的163只矫正视力≥1.0的眼睛进行研究。脉络膜的眼底SS OCT图像用于定量评估大脉络膜血管层的血管密度。还研究了脉络膜血管密度与年龄、性别、屈光不正（RE）、眼轴长度（AL）和黄斑中心凹下脉络膜厚度（SCT）之间的关系。
脉络膜血管密度与受试者年龄之间存在显著负相关（P <.001）。按年龄分析显示，年龄>30岁组存在显著相关性（P <.001），但年龄≤30岁组无显著相关性（P =.225）。SCT与脉络膜血管密度呈显著正相关（P <.001）。然而，未观察到性别、RE或AL与脉络膜血管密度之间存在显著相关性（分别为P =.981、P =.292和P =.216）。以脉络膜血管密度为因变量，年龄、性别、RE、AL和SCT为自变量的多变量回归分析表明，年龄和SCT是脉络膜血管密度的重要决定因素（P <.001）。
年龄和SCT影响脉络膜的血管密度。
