Ruiz-Medrano Jorge, Flores-Moreno Ignacio, Peña-García Pablo, Montero Javier A, Duker Jay S, Ruiz-Moreno José M
*Ophthalmology Unit, Clínico San Carlos University Hospital, Madrid, Spain; †Department of Ophthalmology, Castilla La Mancha University, Albacete, Spain; ‡Ophthalmology Unit, Pío del Río Hortega University Hospital, Valladolid, Spain; §New England Eye Center, Tufts Medical Center, Boston, Massachusetts; and ¶Instituto Europeo de la Retina, Baviera, Spain.
Retina. 2015 Oct;35(10):2067-73. doi: 10.1097/IAE.0000000000000590.
To determine the difference in macular choroidal thickness (CT) profile between eyes in healthy individuals using swept-source optical coherence tomography.
Cross-sectional noninterventional study.
One hundred and forty eyes from 70 healthy patients with spherical equivalent between ± 3 D and with difference ≤ 0.25 D between eyes were scanned using a swept-source optical coherence tomography (Topcon Corporation).
Cross-sectional noninterventional study. One hundred and forty eyes from 70 healthy patients with spherical equivalent between ± 3 D and with difference #0.25 D between eyes were scanned using a swept-source optical coherence tomography (Topcon Corporation). A horizontal CT profile of the macula was created in both eyes by manually measuring the subfoveal CT from the posterior edge of retinal pigment epithelium (RPE) to the choroid/sclera junction. Three determinations were performed at successive points 1,000 mm nasal to the fovea and 5 more temporal to the fovea. The differences in CT between both eyes were analyzed.
Mean age was 25.4 ± 19.9 years (from 4 to 75). The mean spherical equivalent was 0.18 ± 1.37 D (from -3 to +3). Mean macular nasal CT was thicker in the right eye (RE) than in the left eye (LE) (228.11 ± 69.23 μm vs. 212.27 ± 62.71 μm; P = 0.0002; Student's t-test paired data). Mean subfoveal CT and mean temporal CT was not statistically significantly different between the eyes. No statistically significant differences were observed comparing spherical equivalent in the RE compared with the LE. Both men and women showed a thicker mean nasal choroid in the RE versus the left (men, 226.97 ± 61.56 μm vs. 209.87 ± 60.31 μm; women, 229.63 ± 79.39 μm vs. 215.47 ± 66.68 μm, P = 0.003 and P = 0.03, respectively; Student's t-test paired data). At each nasal determination, CT in the RE was statistically significantly thicker than the LE (N1: 283.72 ± 81.10 μm vs. 269.76 ± 75.81 μm [P = 0.001]; in N2: 230.45 ± 73.47 μm vs. 211.33 ± 66.92 μm [P = 0.0002]; and in N3: 170.16 ± 61.00 μm vs. 155.72 ± 53.87 μm [P = 0.008], respectively).
To the best of our knowledge, this is the first report suggesting thicker macular nasal choroid in the RE compared with the LE. In contrast, subfoveal CT and temporal CT were not found to be different between eyes.
使用扫频光学相干断层扫描技术确定健康个体双眼黄斑脉络膜厚度（CT）分布的差异。
横断面非干预性研究。
使用扫频光学相干断层扫描技术（Topcon公司）对70名健康患者的140只眼进行扫描，这些患者的等效球镜度在±3 D之间，双眼差值≤0.25 D。
横断面非干预性研究。使用扫频光学相干断层扫描技术（Topcon公司）对70名健康患者的140只眼进行扫描，这些患者的等效球镜度在±3 D之间，双眼差值≤0.25 D。通过手动测量从视网膜色素上皮（RPE）后缘到脉络膜/巩膜交界处的黄斑中心凹下CT，在双眼创建黄斑的水平CT分布。在黄斑中心凹鼻侧1000 mm处及颞侧另外5个连续点进行三次测量。分析双眼之间的CT差异。
平均年龄为25.4±19.9岁（4至75岁）。平均等效球镜度为0.18±1.37 D（-3至+3）。右眼（RE）的黄斑鼻侧平均CT比左眼（LE）厚（228.11±69.23μm对212.27±62.71μm；P = 0.0002；配对数据的学生t检验）。双眼之间黄斑中心凹下平均CT和颞侧平均CT无统计学显著差异。右眼与左眼的等效球镜度比较未观察到统计学显著差异。男性和女性均显示右眼的鼻侧脉络膜平均厚度大于左眼（男性，226.97±61.56μm对209.87±60.31μm；女性，229.63±79.39μm对215.47±66.68μm，P分别为0.003和0.03；配对数据的学生t检验）。在每次鼻侧测量中，右眼的CT均显著厚于左眼（N1：283.72±81.10μm对269.76±75.81μm [P = 0.001]；N2：230.45±73.47μm对211.33±66.92μm [P = 0.0002]；N3：170.16±61.00μm对155.72±53.87μm [P = 0.008]）。
据我们所知，这是首份表明右眼黄斑鼻侧脉络膜比左眼厚的报告。相比之下，未发现双眼之间黄斑中心凹下CT和颞侧CT存在差异。
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