Fu Min, Zou Chen, Pan Lei, Liang Wei, Qian Hui, Xu Wenrong, Jiang Pengcheng, Zhang Xu
Department of General Surgery, The Affiliated People's Hospital of Jiangsu University, Zhenjiang, Jiangsu 212002, P.R. China.
Jiangsu Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, P.R. China.
Oncol Rep. 2016 Sep;36(3):1207-18. doi: 10.3892/or.2016.4929. Epub 2016 Jul 11.
Long noncoding RNAs (lncRNAs) are emerging as new players in various diseases including cancer. LncRNAs have been shown to play multifaceted roles in the development, progression, and metastasis of cancer. In this review, we highlight the lncRNAs that are critically involved in the pathogenesis of digestive system cancers (DSCs). We summarize the roles of the lncRNAs in DSCs and the underlying mechanisms responsible for their functions. The DSC-associated lncRNAs interact with a wide spectrum of molecules to regulate gene expression at transcriptional, post-transcriptional, and translational levels. We also provide new insights into the clinical significance of these lncRNAs, which are found to be closely associated with the aggressiveness of DSCs and could predict the prognosis of DSC patients. Moreover, lncRNAs have been suggested as promising therapeutic targets in DSCs. Therefore, better understanding of the functional roles of lncRNAs will provide new biomarkers for DSC diagnosis, prognosis, and therapy.
长链非编码RNA（lncRNAs）正在成为包括癌症在内的各种疾病中的新角色。lncRNAs已被证明在癌症的发生、发展和转移中发挥多方面的作用。在本综述中，我们重点介绍了在消化系统癌症（DSCs）发病机制中起关键作用的lncRNAs。我们总结了lncRNAs在DSCs中的作用及其功能的潜在机制。与DSC相关的lncRNAs与多种分子相互作用，在转录、转录后和翻译水平上调节基因表达。我们还对这些lncRNAs的临床意义提供了新的见解，发现它们与DSCs的侵袭性密切相关，并可预测DSC患者的预后。此外，lncRNAs已被认为是DSCs中有前景的治疗靶点。因此，更好地理解lncRNAs的功能作用将为DSC的诊断、预后和治疗提供新的生物标志物。
