职业暴露对甲型H1N1流感大流行病毒感染及住院情况的影响

Effect of Occupational Exposure on A(H1N1)pdm09 Infection and Hospitalization.

作者信息

Pujol Jesús, Godoy Pere, Soldevila Núria, Castilla Jesús, González-Candelas Fernando, Mayoral Jose M, Astray Jenaro, García Susana, Martín Vicente, Tamames Sonia, Delgado Miguel, García Ángela Domínguez

机构信息

Departament de Cirurgia, Universitat de Lleida, Lleida, Spain; Departament de SalutPública, Universitat de Barcelona, Barcelona, Spain;

Public Health Agency, Generalitat de Catalunya, Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain;

出版信息

Ann Occup Hyg. 2016 Oct;60(8):1009-19. doi: 10.1093/annhyg/mew044. Epub 2016 Jul 18.

DOI:10.1093/annhyg/mew044

PMID:27432191

Abstract

OBJECTIVE

To analyze relationships between occupational exposure and influenza infection and hospitalization during the 2009-2010 pandemic wave and the 2010-2011 influenza seasonal epidemic in Spain.

METHODS

Occupations were classified as high, medium, or low risk of influenza exposure. To assess the risk of infection, 588 outpatient cases of influenza confirmed by reverse-transcription polymerase-chain-reaction (RT-PCR) were compared with 588 outpatients without influenza symptoms. To assess the risk of hospitalization, 337 outpatient influenza cases were compared with 337 inpatient influenza cases.

RESULTS

The high risk of occupational exposure group was composed only of health care workers. After adjustment for age, sex, vaccination status, and predictive variables of influenza infection, patients with a high risk of occupational exposure had an aOR of 2.14 (95%CI: 1.25-3.66) of being an outpatient influenza case and an aOR of 0.43 (95%CI: 0.20-0.95) of being an inpatient influenza case, compared with those with a low risk.

CONCLUSIONS

A high risk of occupational exposure is a risk factor for influenza infection but not for hospitalization.

摘要

目的

分析2009 - 2010年大流行波期间以及2010 - 2011年西班牙流感季节性流行期间职业暴露与流感感染及住院之间的关系。

方法

职业被分为流感暴露高、中、低风险类别。为评估感染风险，将588例经逆转录聚合酶链反应（RT-PCR）确诊的流感门诊病例与588例无流感症状的门诊患者进行比较。为评估住院风险，将337例门诊流感病例与337例住院流感病例进行比较。

结果

职业暴露高风险组仅由医护人员组成。在对年龄、性别、疫苗接种状况以及流感感染预测变量进行调整后，与低风险者相比，职业暴露高风险患者成为流感门诊病例的调整后比值比（aOR）为2.14（95%置信区间：1.25 - 3.66），成为流感住院病例的aOR为0.43（95%置信区间：0.20 - 0.95）。