Nishimura Y, Jo S, Akuta K, Masunaga S, Fushiki M, Hiraoka M, Takahashi M, Abe M
Department of Radiology, Faculty of Medicine, Kyoto University, Japan.
Cancer Res. 1989 Aug 1;49(15):4295-7.
The effects of hyperthermia on rabbit hepatic vasculature were studied histologically. To investigate heat-induced vascular damage in the central veins, portal veins, and hepatic arterioles, the left lobes of rabbit liver were heated locally for 30 min in the range of 40-46 degrees C. Hyperthermia was induced by an 8-MHz radiofrequency current heating device using a needle type interstitial applicator. This device allowed application of heat to a central area of 10 x 10 mm no more than 1 degree C below the preset temperature. Within the area of 1 cm2, the percentage of damaged (ruptured or thrombosed) vessels was estimated for each type of hepatic vasculature. Vascular damage following hyperthermia continued up to 24 h after heating for the three types of hepatic vasculature. Central veins were the most thermosensitive followed by portal veins, whereas hepatic arterioles were the most thermoresistant. The temperature causing 50% vascular damage 24 h after heating was 41.5-42.5 degrees C, 42.5-43.5 degrees C, and 44-45 degrees C for central veins, portal veins, and arterioles, respectively. This differential thermal responsiveness of hepatic vasculature may be attributed to the histological structure of the vessels.
采用组织学方法研究了热疗对兔肝脏血管系统的影响。为了研究热诱导的中央静脉、门静脉和肝小动脉的血管损伤，用8MHz射频电流加热装置通过针型组织间施热器对兔肝脏左叶进行局部加热30分钟，加热温度范围为40 - 46℃。该装置可将热量施加到一个10×10mm的中心区域，温度不超过预设温度1℃。在1cm²的区域内，估算每种肝血管类型中受损（破裂或血栓形成）血管的百分比。热疗后三种肝血管类型的血管损伤可持续至加热后24小时。中央静脉对热最敏感，其次是门静脉，而肝小动脉对热最具抵抗力。加热后24小时导致50%血管损伤的温度，中央静脉为41.5 - 42.5℃，门静脉为42.5 - 43.5℃，肝小动脉为44 - 45℃。肝血管这种不同的热反应性可能归因于血管的组织结构。
