Kirdak Turkay, Canturk Nuh Zafer, Korun Nusret, Ocakoglu Gokhan
Department of Surgery, Uludag University Faculty of Medicine, Bursa, Türkiye.
Department of Surgery, Kocaeli University Faculty of Medicine, Kocaeli, Türkiye.
Ann Surg Treat Res. 2016 Jul;91(1):8-16. doi: 10.4174/astr.2016.91.1.8. Epub 2016 Jun 30.
The aim of this study was to define the clinical and laboratory characteristics of patients operated on for primary hyperpatathyroidism (PHPT) at university hospitals in Türkiye, and to investigate the differences in the clinical presentations of the disease between different geographical regions.
Patients operated on for PHPT in the university hospitals of Türkiye were included in the study. The demographic, clinical, and laboratory findings and the operational data of the patients were investigated according to the whole country and to different geographical regions. Comparisons were performed according to whole country and regions.
A total of 1,162 cases were included in the study from different regions and 20 university hospitals. The mean age of patients was 52.4 ± 0.38 (mean ± standard error) in the general population of Türkiye. The rates of hypertension, urolithiasis, bone disease and 25-hydroxyvitamin D insufficiency were 35%, 18.6%, 67.6%, and 63%, respectively. The median parathormone (PTH), serum total calcium (Ca(+2)) and phosphorus value were 220 pg/mL (range, 70-2,500 pg/mL), 11.2 mg/dL (range, 9.5-11.2 mg/dL), and 2.4 mg/dL (range, 1-4.7 mg/dL), respectively. The median size of the adenomas resected was 16 mm (range, 4-70 mm). Significant differences were observed in the clinical and laboratory findings of the patients operated on due to PHPT between different geographical regions of Türkiye (P < 0.05).
The clinical and laboratory characteristics of the patients with PHPT in different geographical regions of Türkiye differ. Furthermore, the general findings of the cases in Türkiye give us a hint that the severity of the disease here is somewhere between Eastern and Western countries.
本研究旨在明确土耳其大学医院原发性甲状旁腺功能亢进症（PHPT）手术患者的临床和实验室特征，并调查不同地理区域该疾病临床表现的差异。
纳入在土耳其大学医院接受PHPT手术的患者。根据全国及不同地理区域对患者的人口统计学、临床、实验室检查结果及手术数据进行调查。按全国和区域进行比较。
来自不同区域和20所大学医院的1162例患者纳入研究。土耳其总体人群中患者的平均年龄为52.4±0.38（均值±标准误）。高血压、尿路结石、骨病和25-羟基维生素D不足的发生率分别为35%、18.6%、67.6%和63%。甲状旁腺激素（PTH）、血清总钙（Ca(+2)）和磷的中位数分别为220 pg/mL（范围70 - 2500 pg/mL）、11.2 mg/dL（范围9.5 - 11.2 mg/dL）和2.4 mg/dL（范围1 - 4.7 mg/dL）。切除腺瘤的中位数大小为16 mm（范围4 - 70 mm）。土耳其不同地理区域因PHPT接受手术患者的临床和实验室检查结果存在显著差异（P < 0.05）。
土耳其不同地理区域PHPT患者的临床和实验室特征不同。此外，土耳其病例的总体结果提示我们，该国该疾病的严重程度介于东方和西方国家之间。
