Shani A, Rozen P, Fink A, Bass D, Fraser D, Bentwich Z
Oncology Unit, Kaplan Hospital, Rehovot, Israel.
Cancer Detect Prev. 1989;13(5-6):311-6.
A study of 191 screenees at high risk for colorectal neoplasm was undertaken to evaluate the value of the leukocyte adherence inhibition (LAI) test in detecting colorectal neoplasms. All screenees underwent total colonoscopy and LAI test. Results show that 94/191 (49.2%) screenees had neoplasms. Overall LAI positivity was 18.3% (35/191), which was highly significant, versus an asymptomatic comparison group (7.5%, 11/146). LAI test sensitivity, specificity, and positive and negative predictive values were, respectively, 19.8, 82.7, 45.7, and 58.5%. In this study the LAI test was not found to be a sensitive screening test for colorectal neoplasms. However, as the LAI test result was a significant finding within the study group, it may possibly be a risk factor and identify a subgroup that will require careful prospective evaluation.
为评估白细胞黏附抑制（LAI）试验在检测结直肠肿瘤方面的价值，对191名结直肠肿瘤高危筛查对象进行了一项研究。所有筛查对象均接受了全结肠镜检查和LAI试验。结果显示，191名筛查对象中有94名（49.2%）患有肿瘤。总体LAI阳性率为18.3%（35/191），与无症状对照组（7.5%，11/146）相比具有高度显著性。LAI试验的敏感性、特异性、阳性预测值和阴性预测值分别为19.8、82.7、45.7和58.5%。在本研究中，未发现LAI试验是结直肠肿瘤的敏感筛查试验。然而，由于LAI试验结果在研究组中是一个显著发现，它可能是一个危险因素，并识别出一个需要仔细前瞻性评估的亚组。
