Titus-Ernstoff L, Ernstoff M S, Kirkwood J M, Barnhill R L, Fine J, Duray P H
Department of Epidemiology, Yale University School of Medicine, New Haven, Connecticut.
Cancer Detect Prev. 1989;13(5-6):317-21.
This report describes the efficacy of skin examination for the early detection of second primary cutaneous melanomas among patients with nonfamilial melanoma. A series of 121 patients with newly diagnosed first primary cutaneous melanomas participated in a study of melanoma and dysplastic nevi. Of the 121 study participants, six patients were subsequently diagnosed with a second primary melanoma. For five of these patients, frequent skin examinations resulted in the detection of second primaries that were shallower in depth than was the first primary melanoma. In four cases, the second primaries were identified in low-risk growth phases (less than 0.76 mm); three of these low-risk tumors were melanoma in situ.
本报告描述了皮肤检查在非家族性黑色素瘤患者中早期发现第二原发性皮肤黑色素瘤的疗效。121例新诊断为原发性皮肤黑色素瘤的患者参与了一项关于黑色素瘤和发育异常痣的研究。在这121名研究参与者中，有6名患者随后被诊断出患有第二原发性黑色素瘤。对于其中5名患者，频繁的皮肤检查发现了深度比第一原发性黑色素瘤浅的第二原发性黑色素瘤。在4例病例中，第二原发性黑色素瘤在低风险生长阶段（小于0.76毫米）被发现；其中3例低风险肿瘤为原位黑色素瘤。
