Landthaler M, Braun-Falco O, Bernreiter F, Hölzel D
Dermatologische Klinik und Poliklinik, Ludwig-Maximilians-Universität München.
Hautarzt. 1992 Jan;43(1):11-5.
The incidence of further malignant tumors was analyzed by means of a retrospective study in 2335 melanoma patients. During the follow up 85 patients (3.64%) developed a second malignant tumor: 29 patients multiple primary malignant melanomas (mm), 49 a mm and a further nonmelanocytic malignant tumor, and 7 multiple primary mm and an additional non-melanocytic malignant tumor. Statistical calculations revealed that female melanoma patients have a 20 fold, and male melanoma patients a 30 fold increased risk to develop further malignant melanomas. In contrast, there was no increased incidence of non-melanocytic malignant tumors, breast carcinoma included. A total skin examination has therefore to be performed during follow up investigations of melanoma patients for early detection of further malignant melanomas.
通过对2335例黑色素瘤患者进行回顾性研究，分析了进一步发生恶性肿瘤的发生率。在随访期间，85例患者（3.64%）发生了第二种恶性肿瘤：29例为多发性原发性恶性黑色素瘤（mm），49例为mm和另一种非黑素细胞性恶性肿瘤，7例为多发性原发性mm和另一种非黑素细胞性恶性肿瘤。统计计算表明，女性黑色素瘤患者发生进一步恶性黑色素瘤的风险增加20倍，男性黑色素瘤患者增加30倍。相比之下，包括乳腺癌在内的非黑素细胞性恶性肿瘤的发生率没有增加。因此，在黑色素瘤患者的随访调查期间必须进行全面的皮肤检查，以便早期发现进一步的恶性黑色素瘤。
