Martires Kathryn J, Cohen Brandon E, Cassarino David S
The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, NY, USA.
Department of Dermatology, New York University, School of Medicine, New York, NY, USA.
J Cutan Pathol. 2016 Nov;43(11):1041-1044. doi: 10.1111/cup.12773. Epub 2016 Aug 26.
Lymphomatoid papulosis (LyP) is classified as a CD30+ primary cutaneous lymphoproliferative disease. The phenotypic variability along the spectrum of CD30+ lymphoproliferative diseases is highlighted by the distinct histologic subtypes of LyP types A, B, C, and the more recently described types D, E, and F. We report the case of an elderly woman with a clinical presentation and histopathologic findings consistent with LyP, whose atypical CD30+ infiltrate uniquely demonstrated a spindle-cell morphology. To our knowledge, this is the first reported case of LyP characterized by CD30+ spindle-shaped cells, and may represent a new and distinct histologic variant of LyP.
淋巴瘤样丘疹病（LyP）被归类为一种CD30阳性的原发性皮肤淋巴细胞增殖性疾病。LyP的A、B、C型以及最近描述的D、E、F型等不同组织学亚型突出了CD30阳性淋巴细胞增殖性疾病谱系中的表型变异性。我们报告了一例老年女性病例，其临床表现和组织病理学发现与LyP一致，其非典型的CD30阳性浸润独特地表现为梭形细胞形态。据我们所知，这是首例以CD30阳性梭形细胞为特征的LyP病例，可能代表LyP一种新的独特组织学变异型。
