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围绕Gal-β-(1→3)-Glc连接键的构象灵活性：水溶液中反式ψ构象存在的实验证据。

Conformational flexibility around the Gal-β-(1 → 3)-Glc linkage: Experimental evidence for the existence of the anti-ψ conformation in aqueous solution.

作者信息

Vidal Paloma, Jiménez-Barbero Jesús, Espinosa Juan F

机构信息

Discovery Chemistry Research and Technologies, Centro de Investigación Lilly, Avenida de la Industria 30, 28108 Alcobendas, Madrid, Spain.

Centro de Investigaciones Biológicas, Ramiro de Maeztu 9, 28040 Madrid, Spain.

出版信息

Carbohydr Res. 2016 Oct 4;433:36-40. doi: 10.1016/j.carres.2016.06.009. Epub 2016 Jul 5.

DOI:10.1016/j.carres.2016.06.009
PMID:27434833
Abstract

NOE-based analysis of the disaccharide β-Gal-(1 → 3)-β-Glc-OMe (1), especially a diagnostic Gal1-Glc4 NOE detected in a HSQC-NOESY spectrum, reveals the existence of the anti-ψ conformer in aqueous solution in addition to the major syn conformer. This result provides experimental proof of conformational flexibility around the aglyconic bond of β-(1 → 3) disaccharides, in contrast to previous studies that suggested that the flexibility around this linkage was restricted to the syn conformational region.

摘要

基于核Overhauser效应（NOE）对二糖β-Gal-(1→3)-β-Glc-OMe（1）进行分析，尤其是在HSQC-NOESY谱图中检测到的诊断性Gal1-Glc4 NOE，揭示了在水溶液中除了主要的顺式构象异构体之外，还存在反式ψ构象异构体。这一结果为β-(1→3)二糖糖苷配基键周围的构象灵活性提供了实验证据，这与之前认为该连接周围的灵活性仅限于顺式构象区域的研究形成对比。

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