J Am Dent Assoc. 2017 Jan;148(1):40-43. doi: 10.1016/j.adaj.2016.06.010. Epub 2016 Jul 18.
Ameloblastoma is an odontogenic tumor predominantly occurring in patients who are in their 20s and 30s. Approximately 10% to 15% of ameloblastomas occur in patients younger than 18 years. Although it is a benign tumor, an ameloblastoma can have a devastating effect on children both physically and emotionally. The aim of this case report is to demonstrate how tissue engineering and surgical techniques can minimize morbidity and recovery time after extirpation and immediate reconstruction of a mandibular ameloblastoma.
An 11-year-old girl was referred for surgical evaluation of a lesion found on a routine dental radiograph. Resection of a mandibular unicystic ameloblastoma resulted, including immediate reconstruction using a costochondral rib graft, allogeneic bone, bone marrow aspirate concentrate, and recombinant human morphogenetic protein-2. One year postoperatively, the patient had no evidence of recurrence as well as excellent mandibular bone height and width with good facial form. The patient has returned to her daily life without any disabilities or disfigurement.
Dentists are typically the first health care providers to discover oral pathology in patients. The coordination of care by the dental care providers and the oral and maxillofacial specialist was key to the successful outcome for this patient. With biotechnology and surgical techniques, the dental surgeon can extirpate an ameloblastoma and reconstruct the mandible defect to the ideal shape and size with minimal morbidity and recovery time.
成釉细胞瘤是一种牙源性肿瘤，主要发生在 20 多岁和 30 多岁的患者中。约有 10%至 15%的成釉细胞瘤发生在 18 岁以下的患者中。尽管它是一种良性肿瘤，但成釉细胞瘤会对儿童的身体和心理造成毁灭性的影响。本病例报告旨在展示组织工程和外科技术如何在切除和即刻重建下颌成釉细胞瘤后最小化发病率和恢复时间。
一名 11 岁女孩因常规牙科 X 光片发现病变而被转介接受手术评估。切除了下颌单囊成釉细胞瘤，包括使用肋软骨移植物、同种异体骨、骨髓抽吸浓缩物和重组人形态发生蛋白-2 进行即刻重建。术后 1 年，患者无复发迹象，下颌骨高度和宽度良好，面部形态良好。患者已恢复正常生活，无任何残疾或毁容。
牙医通常是发现患者口腔病理学的第一医疗保健提供者。牙科保健提供者和口腔颌面专家之间的护理协调是该患者成功治疗的关键。通过生物技术和外科技术，牙医可以切除成釉细胞瘤，并以最小的发病率和恢复时间将下颌骨缺损重建为理想的形状和大小。
