Yamada Hiroko, Ohta Haruka, Hasegawa Shunji, Azuma Yoshihiro, Hasegawa Masanari, Kadoya Ryo, Ohbuchi Noriko, Ohnishi Yuji, Okada Seigo, Hoshide Madoka, Ohga Shouichi
a Department of Pediatrics , Yamaguchi University Graduate School of Medicine , Ube , Japan.
b Division of Pediatrics , Yamaguchi Grand Medical Center , Hofu , Japan.
Hum Vaccin Immunother. 2016 Nov;12(11):2772-2776. doi: 10.1080/21645515.2016.1208329. Epub 2016 Jul 19.
Bacille de Calmette et Guerin (BCG) is the only licensed tuberculosis vaccine to prevent severe tuberculosis. The adverse events of BCG vaccination, including local reactions, lymphadenitis, osteomyelitis, tuberculid, and disseminated infection, have been reported. Two infants presented erythema at the inoculation site of BCG after the resolution of Kawasaki disease (K). They received BCG vaccination 1 week and 6 weeks before the K onset, respectively. Intravenous immunoglobulin improved the K activity, however the skin rash of BCG inoculation site extended to the face and extremities days 24 and 10 after the K onset, respectively. Both bacteriological study and interferon-γ release assay were negative for Mycobacterium tuberculosis infection. These patients were diagnosed as having tuberculid after K. The skin lesions gradually disappeared without antibiotic therapy over 2 months. The development of tuberculid in these patients might be associated with the remnant immune activation of K.
卡介苗（BCG）是唯一一种经许可用于预防严重结核病的疫苗。卡介苗接种的不良事件，包括局部反应、淋巴结炎、骨髓炎、结核疹和播散性感染，均有报道。两名婴儿在川崎病（K）病情缓解后，卡介苗接种部位出现红斑。他们分别在川崎病发病前1周和6周接种了卡介苗。静脉注射免疫球蛋白改善了川崎病病情，然而，卡介苗接种部位的皮疹分别在川崎病发病后第24天和第10天扩展至面部和四肢。结核分枝杆菌感染的细菌学研究和干扰素-γ释放试验均为阴性。这些患者在患川崎病后被诊断为结核疹。皮肤病变在未接受抗生素治疗的情况下，2个月内逐渐消失。这些患者结核疹的发生可能与川崎病残留的免疫激活有关。
