Zaïem Ahmed, El Ferjani Senda, Lakhoua Ghozlane, Sahnoun Rym, Badri Talel, Kastalli Sarrah, Daghfous Riadh, Lakhal Mohamed, El Aidli Sihem
a National Center of Pharmacovigilance; Tunis, Tunisia.
Hum Vaccin Immunother. 2014;10(7):2081-2. doi: 10.4161/hv.28913.
The disseminated BCG infection is a rare and serious complication of bacillus Calmette-Guerin (BCG) vaccine. We report a case of probable disseminated BCG infection in a 10-month-old child who had been vaccinated by BCG vaccine at birth. No incident was noted on the first days of vaccination. At the age of 40 days, she developed left supra clavicular and axillar abcessed lymph nodes. She was treated by surgical flattening of the lymph adenopathy. The same lymph node recurred at the age of 6 months and was treated with surgery. Few weeks after the second episode, cutaneous ulcerative lesions appeared. Cutaneous biopsy was performed and showed lesions compatible with tuberculosis. X-rays showed osteolysis of P1 of the middle finger in the left hand. She was treated by anti-tuberculosis antibiotics.
播散性卡介苗感染是卡介苗(BCG)接种罕见而严重的并发症。我们报告1例10个月大儿童可能发生播散性卡介苗感染,该患儿出生时接种了卡介苗。接种后最初几天未出现异常。40日龄时,她出现左侧锁骨上及腋窝脓肿性淋巴结。通过手术切除肿大淋巴结进行治疗。6月龄时同一淋巴结复发,再次接受手术治疗。第二次发作后数周,出现皮肤溃疡性病变。进行了皮肤活检,结果显示病变符合结核病表现。X线显示左手食指近节指骨骨质溶解。给予抗结核抗生素治疗。