De Pasquale Maria Debora, Mastronuzzi Angela, De Sio Luigi, Serra Annalisa, Grimaldi Chiara, Chinali Marcello, Giordano Ugo
Department of Pediatric Hematology/Oncology and Stem Cell Transplantation, Bambino Gesù Children's Hospital, Piazza Sant'Onofrio, 4, 00165, Rome, Italy.
Pediatric Surgery and Transplantation, Rome, Italy.
BMC Pediatr. 2016 Jul 19;16:99. doi: 10.1186/s12887-016-0628-4.
Takotsubo cardiomyopathy (TC) is characterized by a transient decrease in ejection fraction and a reversible left ventricular dysfunction. The pathophysiology of TC is not completely understood. Heterogeneous and multifactorial mechanisms are involved: drugs, emotional and physical stress, genetic and hormonal factors.
A 17 year-old male with metastatic pancreatic adenocarcinoma, under chemotherapy containing 5-fluorouracil, presented severe left ventricular dysfunction requiring mechanical ventilation and inotropes administration. He completely recovered in 2 weeks.
To our knowledge this is the first report of transient form of ventricular dysfunction, mimicking TC, in an adolescent. We believe that children and adolescents receiving 5-fluorouracil should be closely monitored and referred for investigation if they develop cardiac symptoms.
应激性心肌病（TC）的特征是射血分数短暂下降和可逆的左心室功能障碍。TC的病理生理学尚未完全明确。其涉及多种异质性和多因素机制：药物、情绪和身体应激、遗传和激素因素。
一名17岁转移性胰腺腺癌男性患者，正在接受含5-氟尿嘧啶的化疗，出现严重左心室功能障碍，需要机械通气并给予血管活性药物。他在2周内完全康复。
据我们所知，这是青少年中首例类似TC的短暂性心室功能障碍的报告。我们认为，接受5-氟尿嘧啶治疗的儿童和青少年如果出现心脏症状，应密切监测并转诊进行检查。
