Leeming R J, Hamon C G, Tomkyns J G
Department of Haematology, Birmingham General Hospital, UK.
Clin Chim Acta. 1989 Apr 14;180(3):241-4. doi: 10.1016/0009-8981(89)90005-3.
Folic acid has less effect than 5-formyltetrahydofolic acid (folinic acid) in the alleviation of folate deficiency in cultured HEp 2 cells as measured by the deoxyuridine suppression test. Folic acid inhibits the metabolism of 5-formyltetrahydrofolic acid in vitro, is contraindicated in some cases of clinical folate deficiency and may be inappropriate in others.
