The effect of folic acid and 5-formyltetrahydrofolic acid on folate-deficient HEp 2 cells in culture.
作者信息
Leeming R J, Hamon C G, Tomkyns J G
机构信息
Department of Haematology, Birmingham General Hospital, UK.
出版信息
Clin Chim Acta. 1989 Apr 14;180(3):241-4. doi: 10.1016/0009-8981(89)90005-3.
PMID:2743576
Abstract
Folic acid has less effect than 5-formyltetrahydofolic acid (folinic acid) in the alleviation of folate deficiency in cultured HEp 2 cells as measured by the deoxyuridine suppression test. Folic acid inhibits the metabolism of 5-formyltetrahydrofolic acid in vitro, is contraindicated in some cases of clinical folate deficiency and may be inappropriate in others.
摘要
Zotero 插件