Department of Biological and Environmental Sciences, Gothenburg University, Gothenburg 40530, Sweden.
IFEVA, UBA, CONICET, Facultad de Agronomía, Avenida San Martín 4453, C1417DSE Buenos Aires, Argentina.
Mol Plant. 2016 Oct 10;9(10):1353-1365. doi: 10.1016/j.molp.2016.07.002. Epub 2016 Jul 17.
ELONGATED HYPOCOTYL5 (HY5), a member of the bZIP transcription factor family, inhibits hypocotyl growth and lateral root development, and promotes pigment accumulation in a light-dependent manner in Arabidopsis. Recent research on its role in different processes such as hormone, nutrient, abiotic stress (abscisic acid, salt, cold), and reactive oxygen species signaling pathways clearly places HY5 at the center of a transcriptional network hub. HY5 regulates the transcription of a large number of genes by directly binding to cis-regulatory elements. Recently, HY5 has also been shown to activate its own expression under both visible and UV-B light. Moreover, HY5 acts as a signal that moves from shoot to root to promote nitrate uptake and root growth. Here, we review recent advances on HY5 research in diverse aspects of plant development and highlight still open questions that need to be addressed in the near future for a complete understanding of its function in plant signaling and beyond.
长柱拟南芥 5（HY5）是 bZIP 转录因子家族的一员，它以光依赖的方式抑制下胚轴生长和侧根发育，并促进色素积累。最近对其在激素、营养、非生物胁迫（脱落酸、盐、冷）和活性氧信号通路等不同过程中的作用的研究，将 HY5 置于转录网络中心。HY5 通过直接结合顺式调控元件来调节大量基因的转录。最近还发现，HY5 在可见光和 UV-B 光下都能激活自身的表达。此外，HY5 作为一种信号，从芽移动到根，促进硝酸盐吸收和根生长。在这里，我们综述了 HY5 在植物发育的各个方面的最新研究进展，并强调了仍未解决的问题，这些问题需要在不久的将来得到解决，以全面了解其在植物信号转导中的功能及其它方面的功能。
