Jingu S, Takeshita A, Imaizumi T, Sakai K, Nakamura M
Research Institute of Angiocardiology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Clin Exp Hypertens A. 1989;11 Suppl 1:211-6. doi: 10.3109/10641968909045425.
We examined 1) the relationship between the magnitudes of reflex forearm vasoconstriction during lower body negative pressure (LBNP) at -10 mmHg and ages in 59 subjects whose ages ranged from 24 to 77 years old, and 2) the slopes of the regression lines relating changes in forearm vascular resistance and those in central venous pressure in the three age-groups; those younger than 35 years old (n = 15), those between 35 and 55 years old (n = 12) and those older than 55 years old (n = 12). Forearm blood flow was measured using a strain gauge plethysmograph and forearm vascular resistance was calculated from forearm blood flow and mean blood pressure. There was a significant negative correlation (r = -0.512, p less than 0.01) between age and the magnitude of reflex forearm vasoconstriction during LBNP at -10 mmHg. The slope of the regression line in the old age-group was less (p less than 0.05) than that in the young or middle age-group. Forearm vascular responses to the cold pressor test did not differ among the three age-groups. These results suggest that cardiac receptor control of forearm vascular resistance decreases with aging in humans.
1）59名年龄在24至77岁之间的受试者在-10 mmHg下体负压（LBNP）期间反射性前臂血管收缩幅度与年龄之间的关系；2）三个年龄组中前臂血管阻力变化与中心静脉压变化之间回归线的斜率，这三个年龄组分别为：年龄小于35岁的（n = 15）、年龄在35至55岁之间的（n = 12）和年龄大于55岁的（n = 12）。使用应变片体积描记器测量前臂血流量，并根据前臂血流量和平均血压计算前臂血管阻力。年龄与-10 mmHg LBNP期间反射性前臂血管收缩幅度之间存在显著负相关（r = -0.512，p小于0.01）。老年组回归线的斜率小于年轻或中年组（p小于0.05）。三个年龄组之间对冷加压试验的前臂血管反应没有差异。这些结果表明，人类前臂血管阻力的心脏受体控制随年龄增长而降低。
