Imamura T, Takeshita A, Ashihara T, Yamamoto K, Hoka S, Nakamura M
Circulation. 1985 Jan;71(1):11-6. doi: 10.1161/01.cir.71.1.11.
We sought to determine whether digitalis augments cardiopulmonary baroreflex control of forearm vascular resistance in normal young men. Cardiopulmonary baroreceptor input was reduced with lower body negative pressure (LBNP) at 10 and 20 mm Hg, which decreased central venous pressure but did not alter blood pressure or heart rate. Decreases in forearm blood flow and increases in forearm vascular resistance with LBNP were greater after administration of lanatoside C (Cedilanid) than before, and the slope of the regression line relating changes in central venous pressure and those in forearm vascular resistance was steeper after lanatoside C. Vasoconstrictor responses to the cold pressor test did not differ before and after lanatoside C, which suggested that augmented responses to LBNP after the drug were not caused by a generalized change in reflex control. These results suggest that lanatoside C augments the tonic inhibitory influence of cardiopulmonary baroreceptors in normal men.
我们试图确定洋地黄是否能增强正常年轻男性心肺压力反射对前臂血管阻力的控制。通过10和20毫米汞柱的下体负压（LBNP）降低心肺压力感受器输入，这会降低中心静脉压，但不会改变血压或心率。服用毛花苷C（西地兰）后，LBNP引起的前臂血流量减少和前臂血管阻力增加比服用前更大，并且毛花苷C后中心静脉压变化与前臂血管阻力变化之间的回归线斜率更陡。毛花苷C前后冷加压试验的血管收缩反应没有差异，这表明用药后对LBNP反应增强不是由反射控制的普遍变化引起的。这些结果表明，毛花苷C增强了正常男性心肺压力感受器的紧张性抑制作用。
