Can Ozge, Blount Ben, Valentin-Blasini Liza, Erdemgil Yigit, Uzunoglu Deniz, Aksoy Murat, Coskun Abdurrahman, Serteser Mustafa, Unsal Ibrahim, Ozpinar Aysel
Department of Medical Engineering, Acibadem University, Istanbul, Turkey.
Centers for Disease Control and Prevention, Atlanta, GA, USA.
Bull Environ Contam Toxicol. 2016 Sep;97(3):439-45. doi: 10.1007/s00128-016-1889-1. Epub 2016 Jul 19.
Perchlorate is a chemical pollutant that inhibits iodide uptake and may possibly impair thyroid function. Our previous study found widespread perchlorate exposure in non-pregnant, non-lactating, healthy women residing in Istanbul. The aim of this study is to assess the relative amounts of perchlorate exposure attributable to consumption of municipal water, bottled water and boxed milk available in Istanbul. Only trace levels of perchlorate were found in treated municipal water (58 % detectable, mean = 0.13 µg/L, maximum = 0.75 µg/L) and bottled water (7.4 % detectable, mean = <LOD, maximum = 0.19 µg/L). Conversely, all 30 boxed milk samples contained measurable levels of perchlorate (mean = 4.53 µg/L; maximum = 6.21 µg/L). Median perchlorate exposure attributable to water and milk (0.007 µg/kg/day) is small compared both to the reference dose (0.7 µg/kg/day) and to total perchlorate exposure (0.13 µg/kg/day) in Istanbul. Therefore, additional studies are needed to identify the major sources of perchlorate exposure in Istanbul.
高氯酸盐是一种化学污染物，它会抑制碘的摄取，可能会损害甲状腺功能。我们之前的研究发现，居住在伊斯坦布尔的未怀孕、未哺乳的健康女性普遍接触到高氯酸盐。本研究的目的是评估伊斯坦布尔市售的市政供水、瓶装水和盒装牛奶中高氯酸盐的相对暴露量。在经过处理的市政供水中仅发现痕量水平的高氯酸盐（58%可检测到，平均值=0.13μg/L，最大值=0.75μg/L），瓶装水中的情况类似（7.4%可检测到，平均值=<检测限，最大值=0.19μg/L）。相反，所有30份盒装牛奶样本都含有可测量水平的高氯酸盐（平均值=4.53μg/L；最大值=6.21μg/L）。与参考剂量（0.7μg/kg/天）以及伊斯坦布尔的高氯酸盐总暴露量（0.13μg/kg/天）相比，由水和牛奶导致的高氯酸盐暴露中位数（0.007μg/kg/天）较低。因此，需要进一步研究以确定伊斯坦布尔高氯酸盐暴露的主要来源。
