通过 HF 插入金卡宾合成 α-氟代酮
Synthesis of α-Fluoroketones by Insertion of HF into a Gold Carbene.
机构信息
College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, 2999 North Renmin Lu, Shanghai, 201620, China.
出版信息
Angew Chem Int Ed Engl. 2016 Aug 16;55(34):10032-6. doi: 10.1002/anie.201603914. Epub 2016 Jul 20.
PMID:27436069
Abstract
Reported is an efficient synthesis of α-fluoroketones by insertion of hydrogen fluoride (HF) into the gold carbene intermediate, generated from a cationic gold catalyzed addition of N-oxides to alkynes. This method results in excellent chemical yields for a wide range of alkyne substrates and demonstrates good functional-group tolerance.
摘要
本文报道了一种通过向金卡宾中间体中插入氟化氢（HF）来高效合成α-氟代酮的方法，该金卡宾中间体由阳离子金催化的 N-氧化物与炔烃加成生成。该方法对一系列炔烃底物具有优异的化学收率，并表现出良好的官能团耐受性。
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