Zengin Reyhan, Gençer Nevzat Güneri
Department of Electrical and Electronics Engineering, Middle East Technical University, Ankara, Turkey. Department of Electrical and Electronics Engineering, Selçuk University, Konya, Turkey.
Phys Med Biol. 2016 Aug 21;61(16):5887-905. doi: 10.1088/0031-9155/61/16/5887. Epub 2016 Jul 20.
In this study, magnetic field measurement technique is investigated to image the electrical conductivity properties of biological tissues using Lorentz forces. This technique is based on electrical current induction using ultrasound together with an applied static magnetic field. The magnetic field intensity generated due to induced currents is measured using two coil configurations, namely, a rectangular loop coil and a novel xy coil pair. A time-varying voltage is picked-up and recorded while the acoustic wave propagates along its path. The forward problem of this imaging modality is defined as calculation of the pick-up voltages due to a given acoustic excitation and known body properties. Firstly, the feasibility of the proposed technique is investigated analytically. The basic field equations governing the behaviour of time-varying electromagnetic fields are presented. Secondly, the general formulation of the partial differential equations for the scalar and magnetic vector potentials are derived. To investigate the feasibility of this technique, numerical studies are conducted using a finite element method based software. To sense the pick-up voltages a novel coil configuration (xy coil pairs) is proposed. Two-dimensional numerical geometry with a 16-element linear phased array (LPA) ultrasonic transducer (1 MHz) and a conductive body (breast fat) with five tumorous tissues is modeled. The static magnetic field is assumed to be 4 Tesla. To understand the performance of the imaging system, the sensitivity matrix is analyzed. The sensitivity matrix is obtained for two different locations of LPA transducer with eleven steering angles from [Formula: see text] to [Formula: see text] at intervals of [Formula: see text]. The characteristics of the imaging system are shown with the singular value decomposition (SVD) of the sensitivity matrix. The images are reconstructed with the truncated SVD algorithm. The signal-to-noise ratio in measurements is assumed 80 dB. Simulation studies based on the sensitivity matrix analysis reveal that perturbations with [Formula: see text] mm size can be detected up to a 3.5 cm depth.
在本研究中,对磁场测量技术进行了研究,以利用洛伦兹力对生物组织的电导率特性进行成像。该技术基于利用超声波和外加静磁场感应电流。使用两种线圈配置,即矩形环形线圈和新型xy线圈对,测量感应电流产生的磁场强度。在声波沿其路径传播时,拾取并记录随时间变化的电压。这种成像方式的正向问题定义为根据给定的声激励和已知的人体特性计算拾取电压。首先,通过解析方法研究了所提出技术的可行性。给出了控制时变电磁场行为的基本场方程。其次,推导了标量和磁矢量势的偏微分方程的一般形式。为了研究该技术的可行性,使用基于有限元方法的软件进行了数值研究。为了感应拾取电压,提出了一种新型线圈配置(xy线圈对)。对具有16阵元线性相控阵(LPA)超声换能器(1MHz)和带有五个肿瘤组织的导电体(乳腺脂肪)的二维数值几何模型进行了建模。假设静磁场为4特斯拉。为了了解成像系统的性能,对灵敏度矩阵进行了分析。针对LPA换能器的两个不同位置,以[公式:见原文]为间隔,从[公式:见原文]到[公式:见原文]的11个转向角获得了灵敏度矩阵。通过灵敏度矩阵的奇异值分解(SVD)展示了成像系统的特性。使用截断SVD算法重建图像。假设测量中的信噪比为80dB。基于灵敏度矩阵分析的模拟研究表明,尺寸为[公式:见原文]mm的扰动在深度达3.5cm时可以被检测到。