Center of Micro and Nanochemistry and Engineering, Organische Chemie I, Universität Siegen, Adolf-Reichwein Str. 2, 57068, Siegen, Germany.
Angew Chem Int Ed Engl. 2016 Aug 22;55(35):10512-7. doi: 10.1002/anie.201604658. Epub 2016 Jul 20.
The nanomechanical switch 1 with its three orthogonal binding motifs-the zinc(II) porphyrin, azaterpyridine, and shielded phenanthroline binding station-is quantitatively and reversibly toggled back and forth between four different switching states by means of addition and removal of appropriate metal-ion inputs. Two of the four switching stages are able to initiate catalytic transformations (ON1, ON2), while the two others shut down any reaction (OFF1, OFF2). Thus, in a cyclic four-state switching process the sequential transformation A+B+C→AB+C→ABC can be controlled, which proceeds stepwise along the switching states OFF1→ON1 (click reaction: A+B→AB)→OFF2→ON2 (Michael addition: AB+C→ABC)→OFF1. Two consecutive cycles of the sequential catalysis were realized without loss in activity in a reaction system with eleven different components.
具有三个正交结合基序（锌（II）卟啉、氮杂三联吡啶和屏蔽的菲咯啉结合站）的纳米机械开关 1 通过添加和去除适当的金属离子输入，可在四个不同的开关状态之间进行定量和可逆地来回切换。四个开关阶段中的两个能够启动催化转化（ON1、ON2），而另外两个则关闭任何反应（OFF1、OFF2）。因此，在循环的四态切换过程中，可以控制顺序转化 A+B+C→AB+C→ABC，该转化沿着切换状态 OFF1→ON1（点击反应：A+B→AB）→OFF2→ON2（迈克尔加成：AB+C→ABC）→OFF1 逐步进行。在具有十一个不同组分的反应体系中，实现了两个连续的顺序催化循环，而没有活性损失。
