Center of Micro and Nanochemistry and Engineering, Organische Chemie I, University of Siegen, Adolf-Reichwein Str. 2, 57068, Siegen, Germany.
Chemistry. 2021 Feb 10;27(9):2997-3001. doi: 10.1002/chem.202004416. Epub 2021 Jan 18.
Enzymes are encoded with a gamut of information to catalyze a highly selective transformation by selecting the proper reactants from an intricate mixture of constituents. Mimicking biological machinery, two switchable catalysts with differently sized cavities and allosteric control are conceived that allow complementary size-selective acyl transfer in an on/off manner by modulating the effective local concentration of the substrates. Selective activation of one of two catalysts in a mixture of reactants of similar reactivity enabled upregulation of the desired product.
酶被编码了一系列信息，通过从复杂的成分混合物中选择合适的反应物，来催化高度选择性的转化。受生物机制的启发，设计了两种具有不同大小空腔和变构控制的可切换催化剂，通过调节底物的有效局部浓度，以开/关方式实现互补的尺寸选择性酰基转移。在具有相似反应性的反应物混合物中选择性激活两种催化剂中的一种，可上调所需产物。
