Bae Sun Hwan, Park Se Jin, Kim Wan Seop, Lee Min Woo, Kim Ji Soo
Department of Pediatrics, Konkuk University School of Medicine, Seoul, Korea.
Department of Pathology, Konkuk University School of Medicine, Seoul, Korea.
Pediatr Gastroenterol Hepatol Nutr. 2016 Jun;19(2):143-6. doi: 10.5223/pghn.2016.19.2.143. Epub 2016 Jun 28.
Pediatric mesenteric panniculitis is an extremely rare disease of unknown etiology characterized by chronic inflammation, fat necrosis, and fibrosis in the mesenteric adipose tissue. A previously healthy 13-year-old boy was admitted because of right upper abdominal pain. An abdominal computed tomography scan revealed increased attenuation and enhancement in the left upper abdominal omental fat and anterior peritoneal wall thickening. A laparoscopic biopsy showed mesenteric panniculitis with chronic inflammation, adiponecrosis, and septal fibrosis. Serological tests for autoimmune diseases, nested polymerase chain reaction for Mycobacterium tuberculosis, and special immunohistochemical stains for malignancy were all negative. Symptomatic improvement and improved abnormal findings were achieved after an 8-month treatment with prednisolone according to a follow-up abdominal computed tomography scan. Here, we report a case of pediatric mesenteric panniculitis treated with prednisolone.
小儿肠系膜脂膜炎是一种病因不明的极为罕见的疾病，其特征为肠系膜脂肪组织的慢性炎症、脂肪坏死和纤维化。一名既往健康的13岁男孩因右上腹疼痛入院。腹部计算机断层扫描显示左上腹网膜脂肪密度增加及强化，前腹壁增厚。腹腔镜活检显示肠系膜脂膜炎伴慢性炎症、脂肪坏死和间隔纤维化。自身免疫性疾病的血清学检查、结核分枝杆菌的巢式聚合酶链反应以及恶性肿瘤的特殊免疫组化染色均为阴性。根据随访腹部计算机断层扫描，泼尼松龙治疗8个月后症状改善，异常表现也有所改善。在此，我们报告一例用泼尼松龙治疗的小儿肠系膜脂膜炎病例。
