Dölz R, Heidemann E
Institute of Macromolecular Chemistry, Dept. of Protein and Leather, FRG.
Connect Tissue Res. 1989;18(4):255-68. doi: 10.3109/03008208909019075.
Allysine is a very important crosslink precursor in connective tissue proteins. We describe the reactions of Phthalyl-Allysine-p-Nitrobenzylester, which is a suitable compound to investigate the reactions of the aldehyde group in vitro. Crosslinked compounds are synthesized by mixing suitable stoichiometric amounts of Phthalyl-Allysine-p-Nitrobenzylester and nucleophiles in aqueous organic solvents. The results are compared with the reaction pathways which have been proposed for crosslink synthesis in vivo.
醛赖氨酸是结缔组织蛋白质中一种非常重要的交联前体。我们描述了邻苯二甲酰 - 醛赖氨酸 - 对硝基苄酯的反应，它是一种适合在体外研究醛基反应的化合物。通过在水性有机溶剂中混合适当化学计量的邻苯二甲酰 - 醛赖氨酸 - 对硝基苄酯和亲核试剂来合成交联化合物。将结果与体内交联合成所提出的反应途径进行比较。
