大肠杆菌外膜蛋白中赖氨酰衍生醛类物质
Lysyl-derived aldehydes in outer membrane proteins of Escherichia coli.
作者信息
Diedrich D L, Schnaitman C A
出版信息
Proc Natl Acad Sci U S A. 1978 Aug;75(8):3708-12. doi: 10.1073/pnas.75.8.3708.
Abstract
The major outer membrane proteins from Escherichia coli K-12 are modified to contain alpha-aminoadipic acid delta-semialdehyde (allysine). The allysine was found to be derived from lysine and it was identified by derivatizing it to chloronorleucine by reduction, alpha-aminoadipic acid by oxidation, and to alpha,epsilon-diaminopimelic acid by reacting it with CN- and NH3. The alpha-aminoadipic acid was identified by mass spectrometry. Two major outer membrane proteins were found to possess allysine, a modified lysine characteristically found to connective tissue.
摘要
来自大肠杆菌K-12的主要外膜蛋白经修饰后含有α-氨基己二酸δ-半醛（ε-赖氨酸醛）。发现ε-赖氨酸醛源自赖氨酸，通过还原将其衍生化为氯代正亮氨酸、氧化为α-氨基己二酸以及与CN-和NH3反应将其转化为α,ε-二氨基庚二酸的方法对其进行了鉴定。通过质谱法鉴定了α-氨基己二酸。发现两种主要的外膜蛋白含有ε-赖氨酸醛，这是一种通常在结缔组织中发现的修饰赖氨酸。
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