Davison P F
Boston Biomedical Research Institute, Boston, MA 02114.
Connect Tissue Res. 1989;18(4):293-305. doi: 10.3109/03008208909019078.
The tensile strength of rat tail tendons, measured by the load that ruptures the tendon, varies with the weight of the animal, the vertebra to which the tendon was attached, the pH of the tendon, and the chemical treatment. Reduction with sodium borohydride multiplies the tensile strength by a factor up to 4.5 (the factor diminishing with age) and reduces creep in the strained tendon. It is concluded that strain catalyzes the hydrolysis of aldimine intermolecular crosslinks that contribute significantly to the tensile strength under physiological conditions, and that the crosslinks are stabilized by reduction or with aging. It is postulated that creep is the result of slippage between polymeric assemblies of stably crosslinked molecules. This postulate leads to a plausible description of elongation of connective tissue fibrils in growing animals.
大鼠尾腱的抗张强度通过使腱断裂的负荷来测量，它会因动物体重、腱所附着的椎骨、腱的pH值以及化学处理而有所不同。用硼氢化钠还原可使抗张强度提高至4.5倍（该倍数随年龄增长而降低），并减少受拉腱中的蠕变。得出的结论是，应变催化醛亚胺分子间交联的水解，这些交联在生理条件下对抗张强度有显著贡献，并且交联通过还原或随老化而稳定。据推测，蠕变是稳定交联分子的聚合物组件之间滑动的结果。这一推测为生长动物结缔组织原纤维的伸长提供了一个合理的描述。
