Lee Chung Won, Lee Chiseung, Baek Seungik, Akkoyun Emrah, Ryu Dongman
Department of Thoracic and Cardiovascular Surgery, School of Medicine, Pusan National University, Busan, Republic of Korea.
Biomedical Research Institute, Pusan National University Hospital, Busan, Republic of Korea.
Front Bioeng Biotechnol. 2024 Feb 27;12:1305128. doi: 10.3389/fbioe.2024.1305128. eCollection 2024.
Vascular diseases, such as abdominal aortic aneurysms, are associated with tissue degeneration of the aortic wall, resulting in variations in mechanical properties, such as tissue ultimate stress and a high slope. Variations in the mechanical properties of tissues may be associated with an increase in the number of collagen cross-links. Understanding the effect of collagen cross-linking on tissue mechanical properties can significantly aid in predicting diseased aortic tissue rupture and improve the clarity of decisions regarding surgical procedures. Therefore, this study focused on increasing the density of the aortic tissue through cross-linking and investigating the mechanical properties of the thoracic aortic tissue in relation to density. Uniaxial tensile tests were conducted on the porcine thoracic aorta in four test regions (anterior, posterior, distal, and proximal), two loading directions (circumferential and longitudinal), and density increase rates (0%-12%). As a result, the PPC (Posterior/Proximal/Circumferential) group experienced a higher ultimate stress than the PDC (Posterior/Distal/Circumferential) group. However, this relationship reversed when the specimen density exceeded 3%. In addition, the ultimate stress of the ADC (Anterior/Distal/Circumferential) and PPC group was greater than that of the APC (Anterior/Proximal/Circumferential) group, while these findings were reversed when the specimen density exceeded 6% and 9%, respectively. Finally, the high slope of the PDL (Posterior/Distal/Longitudinal) group was lower than that of the ADL (Anterior/Distal/Longitudinal) group, but the high slope of the PDL group appeared larger due to the stabilization treatment. This highlights the potential impact of density variations on the mechanical properties of specific specimen groups.
血管疾病，如腹主动脉瘤，与主动脉壁的组织退化有关，导致机械性能发生变化，如组织极限应力和高斜率。组织机械性能的变化可能与胶原蛋白交联数量的增加有关。了解胶原蛋白交联对组织机械性能的影响可以显著有助于预测患病主动脉组织的破裂，并提高关于手术程序决策的清晰度。因此，本研究聚焦于通过交联增加主动脉组织的密度，并研究胸主动脉组织机械性能与密度的关系。在猪胸主动脉的四个测试区域（前部、后部、远端和近端）、两个加载方向（周向和纵向）以及密度增加率（0%-12%）下进行了单轴拉伸试验。结果，PPC（后部/近端/周向）组的极限应力高于PDC（后部/远端/周向）组。然而，当样本密度超过3%时，这种关系发生了逆转。此外，ADC（前部/远端/周向）组和PPC组的极限应力大于APC（前部/近端/周向）组，而当样本密度分别超过6%和9%时，这些结果发生了逆转。最后，PDL（后部/远端/纵向）组的高斜率低于ADL（前部/远端/纵向）组，但由于稳定化处理，PDL组的高斜率显得更大。这突出了密度变化对特定样本组机械性能的潜在影响。
