Chang Caiyun, Zhang Ji, Zhou Jingwen, Cao Ruoming, Song Kaijun, Liu Chong, Zhang Xianhui, Geng Xingyi, Liu Xiaoxue, Li Chuanbin
a Jinan Center for Disease Control and Prevention , Jinan , Shandong , China.
Hum Vaccin Immunother. 2016 Nov;12(11):2749-2752. doi: 10.1080/21645515.2016.1208327. Epub 2016 Jul 20.
Use of inactivated poliovirus vaccine (IPV) in Jinan during the polio eradication endgame has not been previously documented. Two IPV-containing vaccines were made available as an option for Jinan parents in 2009. We describe coverage levels and patterns of use of IPV over time using data from the Jinan Childhood Immunization Information Management System (JNCIIMS).
Children born between January 2010 and December 2014 who were registered in JNCIIMS were included in this study. Vaccination records were obtained from JNCIIMS on April 30, 2015. JNCIIMS distinguishes among available poliovirus vaccines; doses administered data were used to describe IPV usage over time. We identified the polio vaccination sequences used by children in the 2012 and 2013 birth cohorts. Coverage estimates were analyzed by birth cohort and migration status. We developed 3 categories for analysis: "resident child," "migrant child" and "other child" according to migration status.
In total, 12,354 (11.7%) IPV, 5,893(5.6%) DTP-IPV-Hib vaccine and 87,054(82.7%) OPV doses were administered to children in the 2010 to 2014 birth cohorts. The proportion of children using an IPV-only schedule increased each year, consistent with the introduction of IPV that is called for by the Polio Eradication Endgame Strategic Plan 2013-2018. During this time, 4.7% children used a schedule containing both IPV and oral poliovirus vaccine (OPV). In the 2012 to 2013 birth cohorts, 14.4% children used an IPV-only schedule; 5.7% children used a sequential schedule, and 79.9% used OPV-only schedule. Use of IPV only schedules was higher among migrant children than among resident children. Among those sequential schedule using both IPV and OPV, 87.2% children used IPV for the first dose and 12.8% used OPV for the first dose.
JNCIIMS provided a mechanism for tracking IPV and OPV vaccination patterns, and showed areas in need of improvement. Ensuring appropriately sequenced IPV and OPV supports reduction of risk of vaccine associated paralytic polio.
在济南消灭脊髓灰质炎的收官阶段使用灭活脊髓灰质炎疫苗（IPV）的情况此前尚无记录。2009年，两种含IPV的疫苗可供济南的家长选择。我们利用济南儿童免疫信息管理系统（JNCIIMS）的数据描述了IPV随时间推移的接种覆盖率和使用模式。
本研究纳入了2010年1月至2014年12月在JNCIIMS登记的儿童。2015年4月30日从JNCIIMS获取了疫苗接种记录。JNCIIMS区分了可用的脊髓灰质炎疫苗；使用接种剂量数据来描述IPV随时间的使用情况。我们确定了2012年和2013年出生队列儿童使用的脊髓灰质炎疫苗接种顺序。根据出生队列和迁移状态分析了接种覆盖率估计值。我们根据迁移状态将分析分为3类：“常住儿童”、“流动儿童”和“其他儿童”。
在2010年至2014年出生队列的儿童中，共接种了12354剂（11.7%）IPV、5893剂（5.6%）百白破-IPV- Hib疫苗和87054剂（82.7%）OPV。仅使用IPV接种程序的儿童比例逐年增加，这与《2013 - 2018年消灭脊髓灰质炎收官战略计划》所要求引入IPV一致。在此期间，4.7%的儿童使用了同时包含IPV和口服脊髓灰质炎疫苗（OPV）的接种程序。在2012年至2013年出生队列中，14.4%的儿童仅使用IPV接种程序；5.7%的儿童使用序贯接种程序，79.9%的儿童仅使用OPV接种程序。流动儿童中仅使用IPV接种程序的比例高于常住儿童。在同时使用IPV和OPV的序贯接种程序中，87.2%的儿童第一剂使用IPV，12.8%的儿童第一剂使用OPV。
JNCIIMS提供了一种跟踪IPV和OPV接种模式的机制，并显示了需要改进的方面。确保IPV和OPV接种顺序恰当有助于降低疫苗相关麻痹性脊髓灰质炎的风险。
