MMWR Morb Mortal Wkly Rep. 2010 May 7;59(17):521-4.
In February 2006, the Advisory Committee on Immunization Practices (ACIP) recommended routine vaccination of all U.S. infants with 3 doses of a pentavalent rotavirus vaccine administered at ages 2, 4, and 6 months. In June 2008, ACIP updated its recommendations to include use of a second rotavirus vaccine, a 2-dose monovalent vaccine, administered at ages 2 and 4 months. The maximum age for the first dose of either rotavirus vaccine (RV) is 14 weeks and 6 days. CDC recently analyzed data from Immunization Information System (IIS) sentinel sites 1) to assess trends in coverage with >or=1 dose of RV during June 2006--June 2009 among infants aged 5 months and 2) to compare RV coverage in the second quarter of 2009 with that of two other routinely-recommended vaccines for U.S. infants: diphtheria, tetanus, and acellular pertussis (DTaP) vaccine, and 7-valent pneumococcal conjugate vaccine (PCV7). RV coverage increased following vaccine introduction and, in June 2009, averaged 72% at the eight currently participating IIS sentinel sites. However, >or=1 dose RV coverage among infants aged 5 months was 13% lower than the average coverage with >or=1 dose of DTaP and PCV7 at these same sites. Lower RV coverage could reflect typical new-vaccine coverage dynamics, the presence of RV-specific barriers, or both. Identifying and reducing barriers to vaccination and educating parents and providers about the health benefits of rotavirus vaccination should increase coverage and help prevent severe rotavirus disease.
2006 年 2 月,免疫实践咨询委员会(ACIP)建议美国所有婴儿常规接种 3 剂五价轮状病毒疫苗,分别在 2、4 和 6 月龄时接种。2008 年 6 月,ACIP 更新了其建议,包括使用第二剂单价轮状病毒疫苗,在 2 月龄和 4 月龄时接种。任何一种轮状病毒疫苗(RV)第一剂的最大年龄为 14 周零 6 天。CDC 最近分析了免疫信息系统(IIS)监测点的数据,1)评估 2006 年 6 月至 2009 年 6 月期间 5 月龄婴儿中至少接种 1 剂 RV 的覆盖情况趋势;2)比较 2009 年第二季度 RV 覆盖率与另外两种美国婴儿常规推荐疫苗:白喉、破伤风和无细胞百日咳(DTaP)疫苗和 7 价肺炎球菌结合疫苗(PCV7)的覆盖率。疫苗接种后,RV 覆盖率有所增加,截至 2009 年 6 月,在 8 个目前参与 IIS 监测点的地区,平均覆盖率为 72%。然而,在 5 月龄婴儿中,至少接种 1 剂 RV 的比例比这些地区同时接种至少 1 剂 DTaP 和 PCV7 的平均覆盖率低 13%。RV 覆盖率较低可能反映了典型的新疫苗覆盖率动态、RV 特定的障碍存在,或者两者兼而有之。识别和减少疫苗接种障碍,并向父母和提供者宣传轮状病毒疫苗接种的健康益处,应能提高覆盖率,有助于预防严重轮状病毒病。