Di Bari Ivana, Picciotto Roberta, Granata Giuseppe, Blanco Anna R, Consoli Grazia M L, Sortino Salvatore
Laboratory of Photochemistry, Department of Drug Science, Viale Andrea Doria 6, 95125, Catania, Italy.
Org Biomol Chem. 2016 Sep 14;14(34):8047-52. doi: 10.1039/c6ob01305h. Epub 2016 Jul 20.
A hydrophobic N-dodecyl-3-(trifluoromethyl)-4-nitrobenzenamine has been synthesized as a suitable NO photodonor and encapsulated in a nanocontainer based on a polycationic calix[4]arene derivative, leading to a supramolecular micellar-like nanoassembly ca. 45 nm in diameter. Visible light excitation of this nanoconstruct triggers NO generation with an efficiency remarkably higher than that observed for the free NO photoreleaser. This amplified NO release results in considerable antibacterial activity against Staphylococcus aureus (ATCC 6538) and Pseudomonas aeruginosa (ATCC 9027) as representative Gram positive and Gram negative bacteria, respectively.
一种疏水性的N-十二烷基-3-(三氟甲基)-4-硝基苯胺已被合成作为一种合适的NO光供体，并被封装在基于聚阳离子杯[4]芳烃衍生物的纳米容器中，形成了一种直径约45 nm的超分子胶束状纳米组装体。这种纳米结构在可见光激发下触发NO生成，其效率显著高于游离NO光释放剂。这种增强的NO释放导致对金黄色葡萄球菌（ATCC 6538）和铜绿假单胞菌（ATCC 9027）分别作为代表性革兰氏阳性和革兰氏阴性细菌具有相当大的抗菌活性。
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