用于活细胞成像的荧光长春碱探针。
Fluorescent vinblastine probes for live cell imaging.
作者信息
Meimetis Labros G, Giedt Randy J, Mikula Hannes, Carlson Jonathan C, Kohler Rainer H, Pirovich David B, Weissleder Ralph
机构信息
Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge Street, CPZN 5206, Boston, Massachusetts 02114, USA.
出版信息
Chem Commun (Camb). 2016 Aug 2;52(64):9953-6. doi: 10.1039/c6cc04129a.
Abstract
Herein we describe the synthesis of several fluorescent analogues of the clinically approved microtubule destabilizing agent vinblastine. The evaluated probes are the most potent described and provides the first example of uptake, distribution and live cell imaging using this well known antimitotic agent.
摘要
在此，我们描述了几种临床批准的微管破坏剂长春碱的荧光类似物的合成。所评估的探针是已描述的最有效的探针，并提供了使用这种著名的抗有丝分裂剂进行摄取、分布和活细胞成像的首个实例。
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