Alkaabi Juma, Gariballa Salah, Sharma Charu, Yasin Javed, Essa Awad Al, Ali Habiba, Souid Abdul-Kader
Department of Internal Medicine, College of Medicine and Health Sciences, UAE University, P.O. Box 17666, Al-Ain, United Arab Emirates.
Department of Nutrition and Health, UAE University, Al-Ain, United Arab Emirates.
BMC Res Notes. 2016 Jul 20;9:355. doi: 10.1186/s13104-016-2160-x.
The prevalence of abdominal obesity among women in UAE is exceptionally high. However, its impact on cardiovascular health has not been adequately investigated. The aims of this study were to investigate: (1) correlations between inflammatory and oxidative biomarkers vs. anthropometric and metabolic measures; (2) rates of dyslipidemia, diabetes, and hypertension and (3) risks of cardiovascular disease.
One hundred ten "healthy" overweight/obese Emirati women attending nutrition counselling clinics were randomly recruited. All participants had completed questionnaire, physical examination and laboratory assessment.
The participants' mean ± SD of age, body mass-index, waist circumference were 39 ± 9 years, 34 ± 6 kg/m(2) and 100 ± 13 cm respectively. Among the studied women 45 % met diagnostic criteria for metabolic syndrome showing a positive correlation of hsCRP with BMI (p = 0.002), body fat (p = 0.002) and waist circumference (p = 0.018). There was positive correlation of IL-6 with waist circumference (p = 0.019) and adiponectin with HDL (p = 0.007). Prevalence of HDL <1.3 mmol/L or triglycerides ≥1.7 mmol/L were 82 %, dysglycemia 31 %, and hypertension 27 and 37 % of women had either 'high' or 'moderate' calculated cardiovascular 10-year risk score.
The levels of inflammatory and oxidative stress markers were highly prevalent among overweight/obese Emirati women and this may predispose to increasing cardiovascular risks at relatively young age. Thus effective strategies to impact cardiovascular burden and conducting outcome studies assessing the increased risk of cardiovascular disease and addressing obesity prevention among women are urgently needed.
阿联酋女性腹部肥胖的患病率极高。然而，其对心血管健康的影响尚未得到充分研究。本研究的目的是调查：（1）炎症和氧化生物标志物与人体测量和代谢指标之间的相关性；（2）血脂异常、糖尿病和高血压的发生率；（3）心血管疾病风险。
随机招募了110名前往营养咨询诊所的“健康”超重/肥胖阿联酋女性。所有参与者均完成了问卷调查、体格检查和实验室评估。
参与者的年龄、体重指数、腰围的平均值±标准差分别为39±9岁、34±6kg/m²和100±13cm。在研究的女性中，45%符合代谢综合征的诊断标准，hsCRP与BMI（p = 0.002）、体脂（p = 0.002）和腰围（p = 0.018）呈正相关。IL-6与腰围呈正相关（p = 0.019），脂联素与高密度脂蛋白呈正相关（p = 0.007）。高密度脂蛋白<1.3mmol/L或甘油三酯≥1.7mmol/L的患病率为82%，血糖异常为31%，高血压为27%，37%的女性有“高”或“中度”计算得出的心血管10年风险评分。
超重/肥胖阿联酋女性中炎症和氧化应激标志物水平普遍较高，这可能使她们在相对年轻时就易患心血管疾病风险增加。因此，迫切需要有效的策略来减轻心血管负担，并开展结果研究，评估心血管疾病风险增加的情况以及解决女性肥胖预防问题。
