Cortijo J, Ortiz J L, Sanz C, Sarría B, Pascual R, Perpiñá M, Esplugues J, Morcillo E J
Departamento de Farmacologia y Farmacotecnia, Universitat de València, Madrid, Spain.
Eur J Pharmacol. 1989 Mar 29;162(3):467-73. doi: 10.1016/0014-2999(89)90337-3.
Active sensitization of guinea-pigs resulted in an increase in responsiveness and sensitivity of tracheal and lung parenchymal strips to CaCl2 (in K+-depolarised tissue), KCl, acetylcholine and histamine. Indomethacin (5 microM) preferentially enhanced the response of tracheal strips from normal animals to histamine and to a lesser extent acetylcholine but not to CaCl2 or KCl. A similar trend was observed in sensitized tissues. Indomethacin pretreatment did not cause changes in responsiveness or sensitivity of lung parenchymal strips from normal or sensitized guinea-pigs to the agonists tested. It is concluded that immunological sensitization produced a non-specific hyperresponsiveness in trachea and lung parenchymal strips. Conversely, cyclooxygenase inhibition by indomethacin elicited a selective increase in the responsiveness to certain agonists in central but not in the peripheral airways.
豚鼠的主动致敏导致气管和肺实质条带对氯化钙（在钾离子去极化组织中）、氯化钾、乙酰胆碱和组胺的反应性和敏感性增加。吲哚美辛（5微摩尔）优先增强正常动物气管条带对组胺的反应，并在较小程度上增强对乙酰胆碱的反应，但对氯化钙或氯化钾无增强作用。在致敏组织中也观察到类似趋势。吲哚美辛预处理并未引起正常或致敏豚鼠肺实质条带对所测试激动剂的反应性或敏感性发生变化。结论是免疫致敏在气管和肺实质条带中产生了非特异性高反应性。相反，吲哚美辛对环氧化酶的抑制作用引起中央气道而非外周气道对某些激动剂反应性的选择性增加。
