Stroev E A, Belkina Z V
Farmakol Toksikol. 1989 Mar-Apr;52(2):74-7.
The experimental findings showed that antidiabetic drugs influence the systems of metabolism of xenobiotics. Insulin, bucarban, glybenclamide, adebit enhance processes of hydroxylation in intact animals. Insulin deficiency in modelled diabetes mellitus produces a weakening of the above processes and administration of the hormone in a therapeutic dose causes normalization of processes of acetylation and hydroxylation. Insulin and glybenclamide enhance processes of acetylation in healthy animals, bucarban and adebit being inductors of microsomal oxidation do not produce such changes. Therefore, in clinical practice one should take into consideration these effects of the antidiabetic drugs in a complex therapy of diabetes mellitus.
实验结果表明，抗糖尿病药物会影响异生物质的代谢系统。胰岛素、布卡班、格列本脲、阿地比特可增强正常动物的羟基化过程。实验性糖尿病模型中的胰岛素缺乏会导致上述过程减弱，而给予治疗剂量的胰岛素会使乙酰化和羟基化过程恢复正常。胰岛素和格列本脲可增强健康动物的乙酰化过程，作为微粒体氧化诱导剂的布卡班和阿地比特则不会产生此类变化。因此，在临床实践中，在糖尿病的综合治疗中应考虑抗糖尿病药物的这些作用。
