Zaks A S, Bykova A A, Evteeva T A
Farmakol Toksikol. 1983 Jul-Aug;46(4):79-82.
Experiments on animals were made to study the diabetogenous effect of repeated administrations of bucarban. The drug-induced immunization and insulin release were accompanied by the increased immune response of the humoral and cellular types specific for bucarban and insulin as well. The changes in the animals' immune status were accompanied by disorders of carbohydrate and lipid metabolism, characteristic for diabetes mellitus and by a lowering of the hypoglycemic effect of the antidiabetic drug in question. It was shown for the first time that the changes in carbohydrate, lipid and lipoprotein blood indicators seen in the animals given sulfanilamide antidiabetics occur in the presence of intense autoimmune response to the body own insulin and are undoubtedly related to this response.
进行了动物实验以研究重复给予布卡班的致糖尿病作用。药物诱导的免疫和胰岛素释放伴随着针对布卡班和胰岛素的体液和细胞类型特异性免疫反应的增强。动物免疫状态的变化伴随着碳水化合物和脂质代谢紊乱，这是糖尿病的特征，并且所研究的抗糖尿病药物的降血糖作用降低。首次表明，给予磺胺类抗糖尿病药物的动物中出现的碳水化合物、脂质和脂蛋白血液指标变化是在对自身胰岛素产生强烈自身免疫反应的情况下发生的，并且无疑与这种反应有关。
