Shruthi Sugumar, Mohan Viswanathan, Amutha Anandakumar, Aravindhan Vivekanandhan
Dept of Genetics, Dr ALM PG IBMS, University of Madras, Taramani, Chennai, India.
Madras Diabetes Research Foundation & Dr. Mohan's Diabetes Specialties Centre, WHO Collaborating Centre for Non-Communicable Diseases Prevention and Control, Chennai, India.
Cytokine. 2016 Oct;86:6-9. doi: 10.1016/j.cyto.2016.07.007. Epub 2016 Jul 18.
The role of adaptive immune cytokines in the pathogenesis of type-1 Diabetes Mellitus (T1DM) is well known. Even though reports on the serum levels of both Th-1 and Th-2 cytokines are available, those on newly described T cell cytokines such as IL-17, IL-33 and IL-9 in T1DM are scarce. We therefore measured the serum levels of both T cell polarizing (IL-33 and IL-12) and T cell effector (IFN-γ, IL-4, IL-10, IL-17 and IL-9) cytokines in T1DM subjects with and without microvascular (retinopathy and nephropathy) complications (MVC). All the tested cytokines were significantly elevated in T1DM subjects except for IFN-γ (which failed to attain statistical significance) with no significant difference between those with and without MVC. From the serum cytokine analysis, no apparent Th polarization could be determined for the T1DM subjects.
适应性免疫细胞因子在1型糖尿病（T1DM）发病机制中的作用已广为人知。尽管有关于Th-1和Th-2细胞因子血清水平的报告，但关于T1DM中新描述的T细胞细胞因子如IL-17、IL-33和IL-9的报告却很少。因此，我们测量了有和无微血管（视网膜病变和肾病）并发症（MVC）的T1DM患者中T细胞极化（IL-33和IL-12）和T细胞效应（IFN-γ、IL-4、IL-10、IL-17和IL-9）细胞因子的血清水平。除IFN-γ（未达到统计学显著性）外，所有检测的细胞因子在T1DM患者中均显著升高，有和无微血管并发症的患者之间无显著差异。从血清细胞因子分析来看，无法确定T1DM患者存在明显的Th极化。
