Barnett J B, Gandy J
Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock 72205.
Fundam Appl Toxicol. 1989 May;12(4):757-64. doi: 10.1016/0272-0590(89)90007-9.
Propanil is a herbicide that is used extensively in rice farming to kill weeds without damaging the rice plant. The immunotoxic effects of acute exposure to propanil were determined in adult C57Bl/6 female mice exposed intraperitoneally to propanil at doses of 0, 10, 25, 50, 100, 200, or 400 mg/kg body wt. One week following exposure, the immune competency of the animals was assessed. Contact hypersensitivity response (CHR), blastogenic response to T- and B-cell-specific mitogens, and mixed lymphocyte reaction (MLR) were significantly depressed only in propanil-treated animals at 400 mg/kg. However, the number of splenic antibody-producing cells was also significantly depressed in a dose-dependent manner at the lower doses of 50, 100, and 200 mg/kg. In addition, a significant reduction in the thymus weight and an increase in absolute and relative spleen weight were also measured in animals treated with 200 and 400 mg/kg. The increase in spleen weight also showed a concomitant rise in spleen cellularity. These data indicate that propanil has a dose-dependent immunotoxic effect on the adult mouse that affects primarily the humoral response.
敌稗是一种广泛用于水稻种植的除草剂，可杀死杂草而不损害水稻植株。通过腹腔注射给予成年C57Bl/6雌性小鼠0、10、25、50、100、200或400 mg/kg体重的敌稗，测定急性暴露于敌稗的免疫毒性作用。暴露一周后，评估动物的免疫能力。仅在接受400 mg/kg敌稗处理的动物中，接触性超敏反应（CHR）、对T细胞和B细胞特异性有丝分裂原的增殖反应以及混合淋巴细胞反应（MLR）显著降低。然而，在50、100和200 mg/kg的较低剂量下，脾抗体产生细胞的数量也以剂量依赖的方式显著降低。此外，在接受200和400 mg/kg处理的动物中，还测量到胸腺重量显著减少，脾脏绝对重量和相对重量增加。脾脏重量的增加还伴随着脾细胞增多。这些数据表明，敌稗对成年小鼠具有剂量依赖性免疫毒性作用，主要影响体液免疫反应。
