Ivy Dunbar
Section of Pediatric Cardiology, Children's Hospital Colorado, University of Colorado School of Medicine, 13123 East 16th Avenue, B100, Aurora, CO 80045, USA.
Cardiol Clin. 2016 Aug;34(3):451-72. doi: 10.1016/j.ccl.2016.04.005.
The prevalence of PH is increasing in the pediatric population, because of improved recognition and increased survival of patients, and remains a significant cause of morbidity and mortality. Recent studies have improved the understanding of pediatric PH, but management remains challenging because of a lack of evidence-based clinical trials. The growing contribution of developmental lung disease requires dedicated research to explore the use of existing therapies as well as the creation of novel therapies. Adequate study of pediatric PH will require multicenter collaboration due to the small numbers of patients, multifactorial disease causes, and practice variability.
由于对儿童患者的识别能力提高以及生存率上升，儿童肺动脉高压（PH）的患病率正在增加，并且仍然是发病和死亡的重要原因。最近的研究增进了对儿童PH的了解，但由于缺乏循证临床试验，其管理仍然具有挑战性。发育性肺部疾病的影响日益增大，这需要开展专门研究，以探索现有疗法的应用以及开发新疗法。鉴于患者数量少、疾病病因多因素以及实践差异，对儿童PH进行充分研究需要多中心合作。
