Samra H K, Ganguly N K, Mahajan R C
Department of Parasitology, Postgraduate Institute of Medical Education and Research, Chandingarh, India.
Gastroenterol Jpn. 1989 Apr;24(2):214-8. doi: 10.1007/BF02774200.
The membrane bound lectin of Giardia lamblia is though to play an important role in the selective colonization of the proximal small intestine by the parasite. The lectin obtained from xenic lysetes of G.lamblia gave a titre of more than 1:2048 in the hemagglutination test with rabbit erythrocytes, whereas the axenic lysates required pre-treatment with proteases (trypsin and pronase) in order to obtain a titre of 1:32. Similar behavior was exhibited by enterocytes of the mouse small intestine when tested for agglutination. The activation of xenic trophofzoites by the intestinal proteases and the probable role of bacterial enzymes has been discussed.
蓝氏贾第鞭毛虫的膜结合凝集素被认为在该寄生虫对近端小肠的选择性定殖中起重要作用。从蓝氏贾第鞭毛虫的共生体裂解物中获得的凝集素，在兔红细胞血凝试验中的滴度超过1:2048，而无菌裂解物则需要用蛋白酶（胰蛋白酶和链霉蛋白酶）预处理，以获得1:32的滴度。小鼠小肠的肠上皮细胞在进行凝集试验时也表现出类似行为。已经讨论了肠道蛋白酶对共生滋养体的激活作用以及细菌酶可能发挥的作用。
