Singh Baljit, Dhiman Abhishek, Kumar Ajay
Department of Chemistry, Himachal Pradesh University, Shimla, 171005, India.
Department of Chemistry, Himachal Pradesh University, Shimla, 171005, India.
Int J Biol Macromol. 2016 Nov;92:390-400. doi: 10.1016/j.ijbiomac.2016.07.060. Epub 2016 Jul 18.
Supramolecular cyclodextrin (CD) hydrogels have occupied an important position in developing the materials for biomedical application. In the present work an attempt has been made to improve the release profile of ciprofloxacin by designing the β- cyclodextrin containing drug delivery system through network formation and supramolecular interactions. The polymer network has been formed by sterculia gum comprising of glucuronic acid and galacturonic acid and carbopol. The polymers have been characterization by cryo-SEMs, FTIR and C solid state (NMR) and swelling studies. This article also discusses drug release, blood compatibility, mucoadhesion, gel strength and antioxidant properties of the polymers. The release of drug from β-CD containing hydrogels was slower and less as compared to the hydrogels without β-CD. Release of drugs from drug loaded hydrogels occurred through non-Fickian diffusion mechanism and release profile best fitted in Korsmeyer-Peppas model. These hydrogels have been found as haemocompatible, mucoadhesive, and antioxidant in nature. Mucoadhesive nature can further provide the site specific nature to drug delivery system in GIT.
超分子环糊精（CD）水凝胶在生物医学应用材料的开发中占据重要地位。在本研究中，尝试通过形成网络和超分子相互作用来设计含β-环糊精的药物递送系统，以改善环丙沙星的释放曲线。聚合物网络由包含葡萄糖醛酸和半乳糖醛酸的苹婆胶和卡波姆形成。通过低温扫描电子显微镜、傅里叶变换红外光谱和碳固态核磁共振对聚合物进行了表征，并进行了溶胀研究。本文还讨论了聚合物的药物释放、血液相容性、粘膜粘附性、凝胶强度和抗氧化性能。与不含β-CD的水凝胶相比，含β-CD的水凝胶中药物的释放更慢且更少。载药水凝胶中药物的释放通过非菲克扩散机制发生，释放曲线最符合Korsmeyer-Peppas模型。已发现这些水凝胶具有血液相容性、粘膜粘附性和抗氧化性。粘膜粘附性可进一步为胃肠道中的药物递送系统提供位点特异性。
