Department of Chemistry, Himachal Pradesh University, Shimla, 171005, India.
Department of Chemistry, Himachal Pradesh University, Shimla, 171005, India.
Int J Biol Macromol. 2018 Mar;108:477-488. doi: 10.1016/j.ijbiomac.2017.12.041. Epub 2017 Dec 8.
The present article is an attempt to explore the potential of the Moringa oleifera gum polysaccharides in network formation with poly(acrylic acid) by radiation induced crosslinking to develop the hydrogel for slow drug delivery applications. Polymers were characterized by Cryo-SEM, AFM and C NMR techniques. Furthermore, drug delivery, network formation and some biomedical properties like blood compatibility, antioxidant activity, mucoadhesion and gel strength of the hydrogels were also determined. The release of ciprofloxacin occurred through non-Fickian diffusion mechanism and release profile best fitted in Korsmeyer-Peppas kinetic model. The hydrogels were found to be pH responsive, mucoadhesive non-thrombogenic, non-haemolytic, and antioxidant in nature. The crosslink density (ρ) and the mesh size (ξ) of the polymer network was observed 3.81×10mol/cm and 38.77nm respectively in pH 7.4 solution.
本文试图探索辣木胶多糖与聚丙烯酸通过辐射交联形成网络的潜力，以开发用于缓控释药物应用的水凝胶。采用 Cryo-SEM、AFM 和 C NMR 技术对聚合物进行了表征。此外，还测定了水凝胶的药物释放、网络形成以及一些生物医学性质，如血液相容性、抗氧化活性、黏膜黏附性和凝胶强度。环丙沙星的释放通过非菲克扩散机制进行，释放曲线最符合 Korsmeyer-Peppas 动力学模型。水凝胶具有 pH 响应性、黏膜黏附性、非血栓形成、非溶血和抗氧化性质。在 pH 7.4 溶液中，聚合物网络的交联密度（ρ）和网格尺寸（ξ）分别为 3.81×10mol/cm 和 38.77nm。
