用于呼吸道、胃肠道和中枢神经系统感染的多重分子诊断方法
Multiplexed Molecular Diagnostics for Respiratory, Gastrointestinal, and Central Nervous System Infections.
作者信息
Hanson Kimberly E, Couturier Marc Roger
机构信息
Divisions of Infectious Diseases.
Clinical Microbiology, University of Utah and ARUP Laboratories, Salt Lake City.
出版信息
Clin Infect Dis. 2016 Nov 15;63(10):1361-1367. doi: 10.1093/cid/ciw494. Epub 2016 Jul 20.
Abstract
The development and implementation of highly multiplexed molecular diagnostic tests have allowed clinical microbiology laboratories to more rapidly and sensitively detect a variety of pathogens directly in clinical specimens. Current US Food and Drug Administration-approved multiplex panels target multiple different organisms simultaneously and can identify the most common pathogens implicated in respiratory viral, gastrointestinal, or central nervous system infections. This review summarizes the test characteristics of available assays, highlights the advantages and limitations of multiplex technology for infectious diseases, and discusses potential utilization of these new tests in clinical practice.
摘要
高度多重分子诊断检测方法的开发与应用，使临床微生物实验室能够更快速、灵敏地直接在临床标本中检测出多种病原体。目前美国食品药品监督管理局批准的多重检测板可同时针对多种不同生物体，并能识别与呼吸道病毒、胃肠道或中枢神经系统感染相关的最常见病原体。本综述总结了现有检测方法的检测特性，强调了多重技术在传染病检测中的优势与局限性，并讨论了这些新检测方法在临床实践中的潜在应用。
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