用去铁胺治疗的阵发性夜间血红蛋白尿患者出现双侧中心性浆液性视网膜病变。
Bilateral central serous retinopathy in a patient with paroxysmal nocturnal hemoglobinuria treated with deferoxamine.
作者信息
Vahdani Kaveh, Makrygiannis Georgios, Kaneshyogan Harikesh, Sian Inderpaul S, Giasin Osama
机构信息
Royal Eye Infirmary, Derriford Hospital, Plymouth - UK.
Bristol Eye Hospital, Bristol - UK.
出版信息
Eur J Ophthalmol. 2016 Nov 4;26(6):e152-e154. doi: 10.5301/ejo.5000840.
PURPOSE
To report a case of acute bilateral central serous retinopathy associated with deferoxamine therapy in the context of paroxysmal nocturnal hemoglobinuria.
METHODS
Spectral-domain optical coherence tomography and fundus autofluorescence were used to investigate posterior segment changes.
RESULTS
A 76-year-old man with paroxysmal nocturnal hemoglobinuria and hereditary spherocytosis was started on deferoxamine for iron overload secondary to previous blood transfusions. Four days after initiation of treatment, he developed bilateral reduced vision and metamorphopsia. He was noted to have bilateral central serous retinopathy. Symptoms and serous retinal detachment resolved rapidly following discontinuation of treatment.
CONCLUSIONS
This case represents the first report of acute bilateral central serous retinopathy associated with deferoxamine therapy. Cessation of deferoxamine resulted in rapid visual recovery.
目的
报告一例阵发性夜间血红蛋白尿患者在接受去铁胺治疗时发生急性双侧中心性浆液性视网膜病变的病例。
方法
采用谱域光学相干断层扫描和眼底自发荧光检查后段变化。
结果
一名76岁患有阵发性夜间血红蛋白尿和遗传性球形红细胞增多症的男性，因既往输血导致铁过载而开始接受去铁胺治疗。治疗开始四天后，他出现双侧视力下降和视物变形。检查发现他患有双侧中心性浆液性视网膜病变。停止治疗后，症状和浆液性视网膜脱离迅速缓解。
结论
本病例是与去铁胺治疗相关的急性双侧中心性浆液性视网膜病变的首例报告。停用去铁胺后视力迅速恢复。
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