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基于临床亚组评估和治疗癫痫:老年起病癫痫和药物难治性部分性发作癫痫

Evaluating and Treating Epilepsy Based on Clinical Subgroups: Elderly Onset Seizure and Medically Resistant Partial-Onset Epilepsy.

作者信息

Johnson Emily L, Krauss Gregory L

机构信息

Department of Neurology, Johns Hopkins School of Medicine, 600 N Wolfe Street, Baltimore, MD 21287, USA.

Department of Neurology, Johns Hopkins School of Medicine, 600 N Wolfe Street, Baltimore, MD 21287, USA.

出版信息

Neurol Clin. 2016 Aug;34(3):595-610. doi: 10.1016/j.ncl.2016.04.004.

Abstract

For optimal treatment, clinicians must recognize key subgroups of patients with epilepsy who have distinctive patterns of seizures, causes, and treatment needs. Particularly important subgroups are patients who develop seizures in their late adult or elderly years and patients with medically resistant epilepsy. Currently the largest age group of patients diagnosed with new-onset epilepsy is older adult and elderly patients; these patients have a rapidly increasing incidence of seizures beginning in the late 50s and represent the graying of America and the influence of vascular risk factors on producing seizures.

摘要

为了实现最佳治疗,临床医生必须识别癫痫患者的关键亚组,这些亚组具有独特的癫痫发作模式、病因和治疗需求。特别重要的亚组是成年晚期或老年期出现癫痫发作的患者以及药物难治性癫痫患者。目前,被诊断为新发癫痫的患者中最大的年龄组是老年和高龄患者;这些患者从50多岁后期开始癫痫发作的发病率迅速上升,代表了美国人口老龄化以及血管危险因素对癫痫发作的影响。

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