Emik Ulku, Unal Yusuf, Arslan Mustafa, Demirel Cengiz Bekir
Department of Anesthesiology and Reanimation, School of Medicine, Gazi University, Ancara, Turquia.
Department of Anesthesiology and Reanimation, School of Medicine, Gazi University, Ancara, Turquia.
Rev Bras Anestesiol. 2016 Sep-Oct;66(5):485-91. doi: 10.1016/j.bjan.2015.03.002. Epub 2016 Jul 18.
Postoperative cognitive dysfunction refers to the problems associated with thought and memory that are often experienced after major surgery. The aim of this study is to evaluate the effects of intraperitoneally administered memantine on recovery, cognitive functions, and pain after propofol anesthesia.
The study was conducted in Gazi University Animal Research Laboratory, Ankara, Turkey in January 2012. Twenty-four adult female Wistar Albino rats weighing 170-270g were educated for 300s in the radial arm maze (RAM) over three days. Group P was administered 150mgkg(-1) of intraperitoneal (IP) propofol; Group M was given 1mgkg(-1) of IP memantine; and Group MP was given 1mgkg(-1) of IP memantine before being administered 150mgkg(-1) of IP propofol. The control group received only IP saline. RAM and hot plate values were obtained after recovery from the groups that received propofol anesthesia and 30min after the administration of drugs in other two groups.
The duration of recovery for Group MP was significantly shorter than Group P (p<0.001), and the number of entries and exits in the RAM by Group MP was significantly higher during the first hour when compared to Group P (p<0.0001). Hot plate values, on the other hand, were found to be significantly increased in all groups when compared to the control values, aside from Group C (p<0.0001).
In this study, memantine provided shorter recovery times, better cognitive functions, and reduced postoperative pain. From this study, we find that memantine has beneficial effects on recovery, cognitive functions, and pain after propofol anesthesia.
术后认知功能障碍是指大手术后常出现的与思维和记忆相关的问题。本研究旨在评估腹腔注射美金刚对丙泊酚麻醉后恢复、认知功能和疼痛的影响。
该研究于2012年1月在土耳其安卡拉的加齐大学动物研究实验室进行。24只体重170 - 270g的成年雌性Wistar白化大鼠在放射状臂迷宫（RAM）中接受了为期三天、每次300秒的训练。P组腹腔注射150mgkg(-1)丙泊酚；M组腹腔注射1mgkg(-1)美金刚；MP组在腹腔注射150mgkg(-1)丙泊酚前先腹腔注射1mgkg(-1)美金刚。对照组仅腹腔注射生理盐水。在接受丙泊酚麻醉的组恢复后以及其他两组给药30分钟后，记录RAM和热板值。
MP组的恢复时间明显短于P组（p<0.001），与P组相比，MP组在第一个小时内进出RAM的次数明显更多（p<0.0001）。另一方面，与对照组相比，除C组外，所有组的热板值均显著升高（p<0.0001）。
在本研究中，美金刚缩短了恢复时间，改善了认知功能，并减轻了术后疼痛。从本研究中，我们发现美金刚对丙泊酚麻醉后的恢复、认知功能和疼痛具有有益作用。
